Yuki N, Takahashi M, Tagawa Y, Kashiwase K, Tadokoro K, Saito K
Department of Biochemistry, Faculty of Medicine, Tokyo Medical and Dental University, Japan.
Ann Neurol. 1997 Jul;42(1):28-33. doi: 10.1002/ana.410420107.
Using Penner's method and Lior's scheme, we serotyped 31 isolates from patients with Guillain-Barré syndrome, 7 isolates from those with Fisher's syndrome, and isolates from patients with sporadic enteritis. PEN 19 of Campylobacter jejuni was isolated more frequently from the Guillain-Barré syndrome patients (16/31 isolates, 52%) than from the sporadic enteritis patients (5%). LIO 7 of C. jejuni also was isolated more frequently from the Gillain-Barré syndrome patients (14/31 isolates, 45%) than from the enteritis patients (3%). One reason why Guillain-Barré syndrome is rare, despite the high incidence of C. jejuni enteritis, may be the low frequencies of PEN 19 and LIO 7. The frequency of positive anti-GM1 antibody titers in the Guillain-Barré syndrome patients with PEN 19 isolates was higher than that in the Guillain-Barré syndrome and Fisher's syndrome patients without PEN 19 isolates. We speculate that the serotypic determinant of PEN 19 aids in the production of anti-GM1 antibody by a GM1-like lipopolysaccharide. In contrast, 5 of the 7 isolates from the Fisher's syndrome patients belonged to PEN 2:LIO 4. The IgG anti-GQ1b antibody was associated with PEN 2 and LIO 4. These serotypic determinants may aid in the production of IgG anti-GQ1b antibody by a GQ1b-like lipopolysaccharide.
我们采用彭纳氏方法和利奥尔氏分型方案，对31株来自吉兰 - 巴雷综合征患者的菌株、7株来自费舍尔综合征患者的菌株以及来自散发性肠炎患者的菌株进行了血清分型。空肠弯曲菌的PEN 19型从吉兰 - 巴雷综合征患者中分离出的频率（16/31株，52%）高于散发性肠炎患者（5%）。空肠弯曲菌的LIO 7型从吉兰 - 巴雷综合征患者中分离出的频率（14/31株，45%）也高于肠炎患者（3%）。尽管空肠弯曲菌肠炎发病率很高，但吉兰 - 巴雷综合征却很罕见，原因之一可能是PEN 19和LIO 7型的频率较低。在分离出PEN 19型菌株的吉兰 - 巴雷综合征患者中，抗GM1抗体滴度阳性的频率高于未分离出PEN 19型菌株的吉兰 - 巴雷综合征和费舍尔综合征患者。我们推测PEN 19型的血清型决定簇通过类似GM1的脂多糖有助于抗GM1抗体的产生。相比之下，费舍尔综合征患者的7株分离菌株中有5株属于PEN 2:LIO 4型。IgG抗GQ1b抗体与PEN 2和LIO 4型相关。这些血清型决定簇可能通过类似GQ1b的脂多糖有助于IgG抗GQ1b抗体的产生。
