低压气腹会增加结肠癌在套管针穿刺部位种植的风险。
Implantation of colon cancer at trocar sites is increased by low pressure pneumoperitoneum.
作者信息
Wu J S, Brasfield E B, Guo L W, Ruiz M, Connett J M, Philpott G W, Jones D B, Fleshman J W
机构信息
Department of Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA.
出版信息
Surgery. 1997 Jul;122(1):1-7. doi: 10.1016/s0039-6060(97)90256-7.
BACKGROUND
The purpose of this study was to determine the effect of pneumoperitoneum on the implantation of tumor at trocar sites.
METHODS
GW-39 human colon cancer cell suspension (0.5 ml of 2.5% v/v) was injected into the peritoneal cavity of golden Syrian hamsters through a 1 cm midline incision. Four 5 mm trocars were inserted through the anterior abdominal wall, and the midline incision was then closed. The animals were randomized to receive pneumoperitoneum (n = 62) or no pneumoperitoneum (n = 60) for 10 minutes. Tumor implantations at trocar sites and midline wound incisions were documented grossly and histologically 8 weeks later.
RESULTS
Tumor was identified in 86% (49 of 57) of control animals and 95% (52 of 55) of the experimental group (p = 0.20). Implants increased with pneumoperitoneum at the midline incision from 44% to 71% (p < 0.01) and at trocar sites from 41% to 64% (p < 0.00001).
CONCLUSIONS
Pneumoperitoneum significantly increased tumor implantation at trocar sites and midline incisions.
背景
本研究的目的是确定气腹对套管针穿刺部位肿瘤种植的影响。
方法
通过1厘米的中线切口将GW - 39人结肠癌细胞悬液（2.5% v/v的0.5毫升）注入金黄叙利亚仓鼠的腹腔。通过前腹壁插入4个5毫米的套管针，然后关闭中线切口。将动物随机分为接受气腹（n = 62）或不接受气腹（n = 60）10分钟。8周后，对套管针穿刺部位和中线伤口切口处的肿瘤种植情况进行大体和组织学记录。
结果
对照组动物中有86%（57只中的49只）发现肿瘤，实验组为95%（55只中的52只）（p = 0.20）。气腹时，中线切口处的种植率从44%增加到71%（p < 0.01），套管针穿刺部位从41%增加到64%（p < 0.00001）。
结论
气腹显著增加了套管针穿刺部位和中线切口处的肿瘤种植。
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