Halpin V J, Underwood R A, Ye D, Cooper D H, Wright M, Hickerson S M, Connett W C, Connett J M, Fleshman J W
Department of Surgery, Washington University School of Medicine, 660 S. Euclid Avenue, Box 8109, St. Louis, MO 63110, USA.
Surg Endosc. 2005 Dec;19(12):1636-40. doi: 10.1007/s00464-005-0005-0. Epub 2005 Oct 5.
The purpose of this study was to assess tumor implantation at abdominal wound sites following manipulation of a solid abdominal tumor.
GW-39 human colon cancer cells were injected into the omentum of golden Syrian hamsters. At 2 weeks, an omental tumor was harvested and animals were randomized to bivalve (A), crush (B), strip (C), or excision (D), with or without pneumoperitoneum. Four 5-mm trocars were inserted into the abdomen, and the tumor was reinserted through the midline, swept through four quadrants, and removed. The incision was closed and pneumoperitoneum at 7 mmHg was maintained for 10 min. Tumor implantation at wound sites was documented at 7 weeks.
Implantation at trocar sites was 53 and 49% with and without pneumoperitoneum in the manipulated groups (A, B, C), respectively (p = 0.993). Implantation at trocar sites was reduced in the control group (D) at 9 and 10% with and without pneumoperitoneum, respectively (p < 0.001).
Tumor implantation at trocar sites is due to spillage of tumor during manipulation and not to pneumoperitoneum.
本研究的目的是评估实体腹部肿瘤操作后腹部伤口部位的肿瘤种植情况。
将GW - 39人结肠癌细胞注入金黄叙利亚仓鼠的大网膜。2周时，切除大网膜肿瘤，动物被随机分为双瓣法（A）、挤压法（B）、剥离法（C）或切除法（D），有无气腹。在腹部插入4个5毫米的套管针，将肿瘤经中线重新插入，扫过四个象限后取出。关闭切口，维持7 mmHg的气腹10分钟。7周时记录伤口部位的肿瘤种植情况。
在操作组（A、B、C）中，有气腹和无气腹时套管针部位的种植率分别为53%和49%（p = 0.993）。对照组（D）中，有气腹和无气腹时套管针部位的种植率分别降至9%和10%（p < 0.001）。
套管针部位的肿瘤种植是由于操作过程中肿瘤的溢出，而非气腹所致。
