Buchholz D H, Squires J E, Herman J H, Ng A T, Anderson J K, Hedberg S L
Fenwal Division, Baxter Biotech, Deerfield, Illinois, USA.
Transfusion. 1997 Jul;37(7):715-8. doi: 10.1046/j.1537-2995.1997.37797369447.x.
Increases in the use of single-donor apheresis components have increased the need for platelet donors. In the United States, persons must weigh 110 pounds or more to qualify as blood donors, and the same weight limitation has been placed on apheresis donors. Because automated plateletpheresis with some instruments differs considerably from whole-blood donation with respect to the volume of blood removed from the donor, the feasibility of using persons weighing between 90 and 110 pounds as platelet donors was evaluated by the use of the CS-3000 blood cell separator.
The study was performed using female subjects who met all usual donor requirements except for minimum weight. The standard platelet collection procedure of the instrument was used, except that the blood processing rate was manually selected so as to optimize the blood withdrawal and return rate in individuals. Vital signs were recorded before and after donation as were signs or symptoms of any type of donor reaction.
Twenty-six of 28 women completed the donation procedure; in two instances, collection was terminated prematurely because of an inability to maintain adequate venous access. An average of 4.5 x 10(11) platelets were collected during a mean donation time of 110 minutes. All donors tolerated the procedure well, and no serious adverse reactions were seen. Because of the administration of priming solution and anticoagulant during apheresis, there was a net positive fluid balance following the procedure, in spite of the removal of approximately 220 mL of platelet concentrate.
These preliminary studies suggest that 90- to 110-pound persons may serve as plateletpheresis donors. Additional studies are needed to more fully document the safety and efficacy of this approach. The use of lower-weight donors may significantly increase the number of persons available to provide single-donor platelet components.
单供体血细胞分离成分使用的增加，使得对血小板供体的需求也相应增加。在美国，个人体重必须达到110磅或以上才有资格成为献血者，血细胞分离供体也有同样的体重限制。由于使用某些仪器进行自动血小板单采与全血捐献相比，从供体采集的血量有很大差异，因此通过使用CS - 3000血细胞分离机评估了体重在90至110磅之间的人作为血小板供体的可行性。
本研究使用的女性受试者除最低体重外，满足所有常规供体要求。采用该仪器的标准血小板采集程序，但手动选择血液处理速率，以优化个体的采血和回血速率。记录捐献前后的生命体征以及任何类型供体反应的体征或症状。
28名女性中有26名完成了捐献程序；在两例中，由于无法维持足够的静脉通路，采集提前终止。平均捐献时间为110分钟，平均采集到4.5×10¹¹个血小板。所有供体对该程序耐受性良好，未观察到严重不良反应。由于在单采过程中使用了预充溶液和抗凝剂，尽管采集了约220 mL血小板浓缩液，但术后仍有净正液体平衡。
这些初步研究表明，体重90至110磅的人可作为血小板单采供体。需要更多研究来更全面地记录这种方法的安全性和有效性。使用体重较轻的供体可能会显著增加可提供单供体血小板成分的人数。
