费雪尼斯阿米库斯血细胞分离机和费森尤斯COM.TEC细胞分离仪血小板单采各方面的比较分析
Comparative Analysis of Various Aspects of Plateletpheresis on the Fenwal Amicus and Fresenius COM.TEC Cell Separator Instruments.
作者信息
Philip Joseph, Biswas Amit Kumar, Chatterjee Tathagata, Mallhi Rajiv Singh
机构信息
Department of Immunohaematology and Blood Transfusion, Armed Forces Medical College, Pune, India.
Department of Immunohaematology and Blood Transfusion, Armed Forces Medical College, Pune, India
出版信息
Lab Med. 2014 Fall;45(4):315-23. doi: 10.1309/LM491RNLMWLFHIMS.
OBJECTIVE
To compare the Fenwal Amicus and the Fresenius COM.TEC apheresis instruments regarding donor peripheral blood parameters, operational variables of the instruments, and quality control parameters of the product obtained.
METHODS
We performed 100 platelet collections from 100 voluntary donors using the 2 studied devices. We measured platelet count using an automated analyzer and analyzed the activation statuses using a flow cytometer.
RESULTS
The median time needed to perform the procedures was significantly longer with the COM.TEC. However, the product we obtained using the Amicus instrument showed higher degrees of platelet-activation. All products we obtained with both instruments had white blood cell counts of less than 5 × 10(6) per bag. We observed no statistical difference regarding collection efficiency and collection rates between the devices.
CONCLUSION
Both instruments collected platelets efficiently, with minimal donor discomfort. Compared with the COM.TEC instrument, the Amicus reached the platelet target yield more quickly; however, it displayed an increase in platelet activation.
目的
比较费森尤斯公司的COM.TEC血细胞分离机和芬华公司的阿米库斯血细胞分离机在供体外周血参数、仪器操作变量以及所获产品质量控制参数方面的差异。
方法
我们使用这两种研究设备，对100名自愿捐献者进行了100次血小板采集。我们使用自动分析仪测量血小板计数，并使用流式细胞仪分析激活状态。
结果
使用COM.TEC血细胞分离机进行操作所需的中位时间明显更长。然而，我们使用阿米库斯仪器获得的产品显示出更高程度的血小板激活。我们使用这两种仪器获得的所有产品每袋白细胞计数均低于5×10⁶。我们观察到这两种设备在采集效率和采集率方面没有统计学差异。
结论
两种仪器均能有效采集血小板，且供体不适最小。与COM.TEC仪器相比，阿米库斯能更快达到血小板目标产量；然而，它显示出血小板激活增加。
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