Buono J P, Déchelotte P, Glowaczower E, Darcha C, Chassagne J, Canis M, Mage G
Service de gynécologie-obstétrique et médecine de la reproduction, Hôtel-Dieu, Clermont-Ferrand.
Ann Pathol. 1995;15(2):134-7.
The authors studied DNA content in a case of small cell carcinoma with hypercalcemia. This tumor exhibited typical clinical, histological, immuno-histochemical, ultrastructural and biological patterns. DNA content was measured both by flow and image cytometry performed on unfixed tumoral samples. The proliferation index was 10%. These results are similar to those of the literature obtained retrospectively from 10% formalin fixed tissues. The DNA content is a clue to distinguish this entity from other small cell carcinomas of the ovary because immunohistochemical findings are not always informative. The diagnosis of small cell carcinoma of hypercalcemic type should be questioned if DNA content is abnormal.
作者研究了一例伴有高钙血症的小细胞癌的DNA含量。该肿瘤表现出典型的临床、组织学、免疫组织化学、超微结构和生物学特征。通过对未固定肿瘤样本进行流式细胞术和图像细胞术来测量DNA含量。增殖指数为10%。这些结果与从10%福尔马林固定组织中回顾性获得的文献结果相似。DNA含量是将该实体与其他卵巢小细胞癌区分开来的线索，因为免疫组织化学结果并不总是具有诊断意义。如果DNA含量异常，应怀疑高钙血症型小细胞癌的诊断。
