Colocousis J S, Huntsman L L, Curreri P W
Circulation. 1977 Dec;56(6):914-7. doi: 10.1161/01.cir.56.6.914.
The purpose of this study was to conduct a controlled evaluation of the continuous-wave Doppler technique for the estimation of stroke volume changes. Six anesthetized dogs were studied. Aortic blood velocity was recorded from the suprasternal notch by a special continuous-wave Doppler unit. Cardiac output was varied by fluid infusion and exsanguination, and over 300 simultaneous records of aortic blood velocity and thermodilution cardiac output were taken. Average stroke volume and average systolic velocity integral (SVI), the area under the Doppler velocity curve were calculated. The relationship of SVI to stroke volume was evaluated for each animal using linear regression. Average results were: correlation coefficient 0.95 +/- 0.04 SD; y-intercept 0.38 +/- 0.14 cm(SD); standare error of fit 0.29 +/- 0.03 cm (SD). These data show that the systolic integral of aortic blood velocity was essentially directly proportional to stroke volume, even over a six-fold range. Thus, this technique will provide an accurate non-invasive estimate of changes in stroke volume.
本研究的目的是对连续波多普勒技术用于估计每搏输出量变化进行对照评估。研究了6只麻醉犬。通过一个特殊的连续波多普勒装置从胸骨上切迹记录主动脉血流速度。通过输液和放血改变心输出量，并同时获取300多条主动脉血流速度和热稀释法心输出量的记录。计算平均每搏输出量和平均收缩期速度积分（SVI），即多普勒速度曲线下的面积。使用线性回归评估每只动物SVI与每搏输出量的关系。平均结果为：相关系数0.95±0.04标准差；截距0.38±0.14厘米（标准差）；拟合标准误差0.29±0.03厘米（标准差）。这些数据表明，即使在六倍的范围内，主动脉血流速度的收缩期积分与每搏输出量基本成正比。因此，该技术将提供准确的非侵入性每搏输出量变化估计。
