Halbreich U
State University of New York at Buffalo, SUNY Clinical Center 14215, USA.
Psychopharmacol Bull. 1997;33(2):281-6.
The better understanding of how hormones modulate cognition and behavior is associated with the application of hormones as psychotropic medications. Several natural and synthetic hormones are used as adjuncts to antidepressant medications or as treatments in their own right. We discuss pharmacotherapeutical aspects of estrogen, thyroid hormones, cortisol suppressors, and melatonin as examples of current trends in the field. In addition to the putative roles of these hormones in the treatment of affective disorders, estrogen might also be used as a cognition-enhancer, and both estrogen and thyroid hormones might have roles as mood stabilizers. The psychotropic effects of melatonin have recently received significant attention, but the exact role of that hormone still needs to be clarified.
对激素如何调节认知和行为的更深入理解与将激素用作精神药物有关。几种天然和合成激素被用作抗抑郁药物的辅助药物或本身就是治疗手段。我们将讨论雌激素、甲状腺激素、皮质醇抑制剂和褪黑素的药物治疗方面，以此为例说明该领域的当前趋势。除了这些激素在情感障碍治疗中的假定作用外，雌激素还可作为认知增强剂，雌激素和甲状腺激素都可能具有情绪稳定剂的作用。褪黑素的精神otropic作用最近受到了广泛关注，但其确切作用仍有待阐明。
