Heidenreich W F, Luebeck E G, Moolgavkar S H
GSF-National Research Center for Environment and Health, Institute for Radiation Protection, Neuherberg, Germany.
Risk Anal. 1997 Jun;17(3):391-9. doi: 10.1111/j.1539-6924.1997.tb00878.x.
We discuss the hazard function of the two-mutation clonal expansion model with time-dependent parameters, with particular emphasis on identifiability of the parameters. We explicitly construct identifiable parameter combinations, and illustrate the properties of the hazard function under perturbations of the underlying biological parameters.
我们讨论了具有时间依赖性参数的双突变克隆扩增模型的风险函数，特别强调了参数的可识别性。我们明确构建了可识别的参数组合，并说明了潜在生物学参数扰动下风险函数的性质。
