Antonov O S, Flegontov V B, Chasovskikh G G
Cor Vasa. 1977;19(3):228-36.
Possibilities of involution of changes in lesser circulation after closure of experimental aortopulmonary anastomosis were studied. 37 observations at various intervals after closure of anastomosis (several minutes to 13.5 months) in 25 dogs were analyzed. Before closure the anastomosis had functioned for 1-7 months. The results of histological examinations of lungs, pressure measurements in lesser circulation, heart weight, electrocardiographic and spirographic examinations were analyzed. It was found that complete involution of changes in lesser circulation was possible only in first month of existence of anastomosis, in this case with changes of both "early" and "late" types. "Late"-type changes after four months function of anastomosis had both reversible and irreversible character, whereas "early"-type changes became irreversible already after three-month duration of anastomosis. With the "late"-type changes, the operation itself (closure of anastomosis) was accompanied by symptoms of pulmonary vasomotor paresis and heart failure, whereas in the presence of "early"-type changes the operation elicited no morphological or functional changes.
研究了实验性主肺动脉吻合口关闭后肺循环改变的 involution 可能性。分析了25只狗在吻合口关闭后不同时间间隔（几分钟至13.5个月）的37次观察结果。在关闭之前，吻合口已发挥作用1 - 7个月。分析了肺组织学检查结果、肺循环压力测量、心脏重量、心电图和呼吸描记图检查结果。发现仅在吻合口存在的第一个月，肺循环改变才有可能完全 involution，在这种情况下，“早期”和“晚期”类型的改变都有。吻合口功能四个月后的“晚期”类型改变具有可逆和不可逆的特征，而“早期”类型改变在吻合口持续三个月后就已变得不可逆。对于“晚期”类型改变，手术本身（吻合口关闭）伴有肺血管运动性麻痹和心力衰竭的症状，而在存在“早期”类型改变的情况下，手术未引起形态学或功能改变。
