Kornau H C, Seeburg P H, Kennedy M B
Department of Molecular Neurobiology, Max-Planck Institute for Medical Research, Jahnstrasse 29, 69120, Heidelberg, Germany.
Curr Opin Neurobiol. 1997 Jun;7(3):368-73. doi: 10.1016/s0959-4388(97)80064-5.
The complex anatomy of neurons demands a high degree of functional organization. Therefore, membrane receptors and ion channels are often localized to selected subcellular sites and coupled to specific signal transduction machineries. PDZ domains have come into focus as protein interaction modules that mediate the binding of a class of submembraneous proteins to membrane receptors and ion channels and thus subserve these organizational aspects. The structures of two PDZ domains have been resolved, which has led to a structural understanding of the specificity of interactions of various PDZ domains with their respective partners. The functional implications of PDZ domain interactions are now being addressed in vitro and in vivo.
神经元复杂的解剖结构需要高度的功能组织。因此，膜受体和离子通道常常定位于特定的亚细胞位点，并与特定的信号转导机制相偶联。PDZ结构域作为蛋白质相互作用模块已受到关注，它介导一类膜下蛋白质与膜受体及离子通道的结合，从而有助于这些组织方面的功能。现已解析出两个PDZ结构域的结构，这使得人们能够从结构上理解各种PDZ结构域与其各自配体相互作用的特异性。目前正在体外和体内研究PDZ结构域相互作用的功能意义。
