将狒狒作为非人灵长类动物模型，用于评估b型流感嗜血杆菌多糖疫苗母体免疫的效果。
The baboon as a nonhuman primate model for assessing the effects of maternal immunization with Haemophilus influenzae type b polysaccharide vaccines.
作者信息
Shearer M H, Lucas A H, Anderson P W, Carey K D, Jenson H B, Chanh T C, Stanley J R, Kennedy R C
机构信息
Department of Microbiology and Immunology, University of Oklahoma Health Science Center, Oklahoma City 73190, USA.
出版信息
Infect Immun. 1997 Aug;65(8):3267-70. doi: 10.1128/iai.65.8.3267-3270.1997.
Abstract
These studies were performed to assess the utility of the baboon as a nonhuman primate model to evaluate vaccines for use in humans. Specifically, we examined the antibody response of baboons immunized during the third trimester of pregnancy with Haemophilus influenzae type b (Hib) polyribosylribitol phosphate (PRP) conjugate and unconjugated polysaccharide vaccines. Some of the vaccinated mothers failed to respond to a single immunization with unconjugated Hib PRP. Specific Hib PRP immunoglobulin G (IgG) but not IgM antibodies cross the baboon placenta and are detected in the offspring. Higher-titer baboon anti-Hib PRP did not express two previously defined cross-reactive human anti-Hib PRP idiotypes and was biased towards lambda light-chain expression. Spectrotype analysis indicated that baboon anti-Hib PRP was restricted in heterogeneity and oligoclonal.
摘要
进行这些研究是为了评估狒狒作为非人类灵长类动物模型在评估用于人类的疫苗方面的效用。具体而言，我们检测了在孕期第三个月用b型流感嗜血杆菌（Hib）多聚核糖基核糖醇磷酸酯（PRP）结合疫苗和未结合多糖疫苗免疫的狒狒的抗体反应。一些接种疫苗的母亲对未结合的Hib PRP单次免疫无反应。特异性Hib PRP免疫球蛋白G（IgG）而非IgM抗体可穿过狒狒胎盘并在后代中检测到。高滴度的狒狒抗Hib PRP不表达两种先前定义的交叉反应性人类抗Hib PRP独特型，且偏向于λ轻链表达。谱型分析表明，狒狒抗Hib PRP在异质性方面受限且为寡克隆性。
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