Seoane J, Vázquez J, Romero M A, Aguado A, Pomareda M
Cirugía Oral y Maxilofacial, Facultad de Medicina Odontología, Santiago de Compostela.
Acta Otorrinolaringol Esp. 1997 Apr;48(3):251-3.
Photochemotherapy with 8-methoxypsoralenes and PUVA has been found to be effective in the treatment of superficial skin inflammations, such as lichen planus. However, there is little bibliography on the treatment of oral lichen planus with PUVA. A case of oral erosive lichen planus was treated with oral psoralenes (0.6 mg/kg body weight) two hours before ultraviolet exposure. Twenty sessions were held, three weekly, for a total cumulative dose of 35.9 J/cm2. After treatment concluded, clinical symptoms and erosive lesions disappeared. PUVA therapy may be useful for severe forms of erosive oral lichen planus that do not respond to conventional treatment.
已发现8-甲氧基补骨脂素和补骨脂素紫外线A光化学疗法对治疗扁平苔藓等浅表性皮肤炎症有效。然而,关于补骨脂素紫外线A光化学疗法治疗口腔扁平苔藓的文献很少。1例口腔糜烂性扁平苔藓患者在紫外线照射前两小时口服补骨脂素(0.6mg/kg体重)。共进行了20次治疗,每周3次,总累积剂量为35.9J/cm²。治疗结束后,临床症状和糜烂性病变消失。补骨脂素紫外线A光化学疗法可能对常规治疗无效的严重口腔糜烂性扁平苔藓有用。