胰腺β细胞中燃料感应系统的基本生化设计特征。
Essential biochemical design features of the fuel-sensing system in pancreatic beta-cells.
作者信息
Matschinsky F M, Collins H W
机构信息
Diabetes Research Center, University of Pennsylvania School of Medicine, 501 Stemmler Hall, 36th and Hamilton Walk, Philadelphia, PA 19104-6015, USA.
出版信息
Chem Biol. 1997 Apr;4(4):249-57. doi: 10.1016/s1074-5521(97)90068-5.
PMID:9235288
Abstract
The beta-cells of the pancreas control the blood levels of glucose and other nutrients by secreting insulin. They sense blood nutrient levels not by using a classical receptor-signaling system, but by detecting the products of nutrient metabolism. Mutations in this pathway can cause diabetes or hypoglycemia.
摘要
胰腺的β细胞通过分泌胰岛素来控制血液中葡萄糖和其他营养物质的水平。它们并非通过经典的受体信号系统来感知血液中的营养物质水平，而是通过检测营养物质代谢的产物来实现。该信号通路中的突变可导致糖尿病或低血糖症。
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