纳洛酮可逆性外周电镇痛在完整大鼠和脊髓大鼠中的作用
Naloxone-reversible peripheral electroanalgesia in intact and spinal rats.
作者信息
Woolf C J, Barrett G D, Mitchell D, Myers R A
出版信息
Eur J Pharmacol. 1977 Oct 1;45(3):311-4. doi: 10.1016/0014-2999(77)90016-4.
PMID:923640
Abstract
Peripheral electrical stimulation of the rat produced a "dose-dependent" analgesia both in intact and in spinal animals. Naloxone, a narcotic antagonist, almost completely reversed this analgesia. It is felt that peripheral electroanalgesia acts via the release of endogenous narcotic-like substances, the enkephalins, at spinal and supraspinal centres.
摘要
对大鼠进行外周电刺激，无论是在未受损的动物还是脊髓动物中，均可产生“剂量依赖性”镇痛作用。麻醉拮抗剂纳洛酮几乎能完全逆转这种镇痛作用。据认为，外周电镇痛是通过在脊髓和脊髓以上中枢释放内源性类阿片物质（脑啡肽）来发挥作用的。
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