Laubie M, Schmitt H, Vincent M, Remond G
Eur J Pharmacol. 1977 Nov 1;46(1):67-71. doi: 10.1016/0014-2999(77)90146-7.
Morphinomimetic peptides were injected into the cisterna magna of chloralosed dogs. Methionine enkepalin (500 microgram/kg i.c.) was found ineffective but beta-endorphin (50 microgram/kg i.c.) induced an initial and transient increase in blood pressure and heart rate followed by a delayed hypotension and bradycardia. The synthetic pentapeptides, [d-ala2]met-enkephalin (500 microgram/kg i.c.), [d-ala2]met-enkephalinamide 500 microgram/kg i.c.) also induced a marked hypotensive, bradycardic and sympatho-inhibitory effect. High doses of naloxone (100 microgram/kg i.v.) were required to antagonize these effects transiently.
将拟吗啡肽注射到水合氯醛麻醉犬的脑大池内。发现甲硫氨酸脑啡肽（500微克/千克，脑池内注射）无效，但β-内啡肽（50微克/千克，脑池内注射）可引起血压和心率的初始短暂升高，随后出现延迟性低血压和心动过缓。合成五肽，[d-丙氨酸2]甲硫氨酸脑啡肽（500微克/千克，脑池内注射）、[d-丙氨酸2]甲硫氨酸脑啡肽酰胺（500微克/千克，脑池内注射）也可引起明显的降压、减慢心率和抑制交感神经作用。需要高剂量的纳洛酮（100微克/千克，静脉注射）才能短暂拮抗这些作用。
