Arienti G, Polci A, Carlini E, Palmerini C A
Istituto di Biochimica e Chimica Medica, Perugia, Italy.
FEBS Lett. 1997 Jun 30;410(2-3):343-6. doi: 10.1016/s0014-5793(97)00655-8.
Prostasomes are vesicles present in human semen. They are secreted by the prostate and contain large amounts of cholesterol and sphingomyelin. Some of their proteins are enzymes. Prostasomes are involved in a number of biological functions. In previous papers we demonstrated that lipid can be transferred from prostasomes to sperm by a fusion process occurring at neutral or slightly acidic pH. In this paper we demonstrate that CD26/dipeptidyl peptidase IV, an enzymatic activity absent in sperm, is transferred to sperm from prostasomes. This may be of particular interest since, by this procedure, sperm may acquire new membrane-bound enzymes and modify the catalytic activity of their surface.
前列腺小体是存在于人类精液中的小泡。它们由前列腺分泌，含有大量胆固醇和鞘磷脂。其一些蛋白质是酶。前列腺小体参与多种生物学功能。在之前的论文中，我们证明脂质可通过在中性或略酸性pH条件下发生的融合过程从前列腺小体转移至精子。在本文中，我们证明精子中不存在的酶活性——CD26/二肽基肽酶IV可从前列腺小体转移至精子。这可能特别有趣，因为通过这个过程，精子可能获得新的膜结合酶并改变其表面的催化活性。
