Kalayanarooj S, Vaughn D W, Nimmannitya S, Green S, Suntayakorn S, Kunentrasai N, Viramitrachai W, Ratanachu-eke S, Kiatpolpoj S, Innis B L, Rothman A L, Nisalak A, Ennis F A
Bangkok Children's Hospital, Department of Virology, Armed Forces Research Institute of Medical Sciences, Thailand.
J Infect Dis. 1997 Aug;176(2):313-21. doi: 10.1086/514047.
A prospective observational study was conducted to identify early indicators of acute dengue virus infection. Children with fever for <72 h without obvious cause were studied at hospitals in Bangkok and Kamphaeng Phet, Thailand, until resolution of fever. Of 172 evaluable subjects (91% of enrollees), 60 (35%) had dengue, including 32 with dengue fever (DF) and 28 with dengue hemorrhagic fever (DHF). At enrollment, children with dengue were more likely than children with other febrile illnesses (OFI) to report anorexia, nausea, and vomiting and to have a positive tourniquet test, and they had lower total white blood cell counts, absolute neutrophil and absolute monocyte counts, and higher plasma alanine and aspartate (AST) aminotransferase levels than children with OFI. Plasma AST levels were higher in children who developed DHF than in those with DF. These data identify simple clinical and laboratory parameters that help to identify children with DF or DHF.
开展了一项前瞻性观察性研究，以确定急性登革病毒感染的早期指标。在泰国曼谷和甘烹碧的医院对无明显病因发热<72小时的儿童进行研究，直至热退。在172名可评估受试者（占入组者的91%）中，60名（35%）患有登革热，其中32例为登革热（DF），28例为登革出血热（DHF）。在入组时，与其他发热性疾病（OFI）儿童相比，登革热儿童更易出现厌食、恶心和呕吐，束臂试验呈阳性，且其白细胞总数、绝对中性粒细胞和绝对单核细胞计数更低，血浆丙氨酸和天冬氨酸（AST）转氨酶水平高于OFI儿童。发生DHF的儿童血浆AST水平高于DF儿童。这些数据确定了有助于识别DF或DHF儿童的简单临床和实验室参数。
