Baldwin J J
Pharmacopeia Inc., Princeton, NJ 08540, USA.
Mol Divers. 1996 Oct;2(1-2):81-8. doi: 10.1007/BF01718704.
With the advent of combinatorial chemistry a new paradigm is evolving in the field of drug discovery. The approach is based on an integration of chemistry, high-throughput screening and automation engineering. The chemistry arm is usually based on solid-phase synthesis technology as the preferred approach to library construction. One of the most powerful of the solid-phase methods is encoded split synthesis, in which the reaction history experience by each polymeric bead is unambiguously recorded. This split-and-pool approach, employing chemically robust tags, was used to construct a 85,000-membered dihydrobenzopyran library.
随着组合化学的出现，药物发现领域正在演变一种新的模式。该方法基于化学、高通量筛选和自动化工程的整合。化学方面通常基于固相合成技术作为构建文库的首选方法。编码拆分合成是最强大的固相方法之一，其中每个聚合物珠粒经历的反应历史都被明确记录。这种采用化学稳定标签的拆分合并方法被用于构建一个含有85000个成员的二氢苯并吡喃文库。
