Wang S, Krinks M, Moos M
Laboratory of Developmental Biology, Center for Biologics Evaluation and Research, Food and Drug Administration, Bethesda, Maryland 20892, USA.
Biochem Biophys Res Commun. 1997 Jul 18;236(2):502-4. doi: 10.1006/bbrc.1997.6995.
Frzb-1 is a secreted factor that was recently shown to inhibit signaling by Wnts 1 and 8. Frzb-1 contains an amino terminal domain that is homologous to the Drosophila polarity gene frizzled; several other secreted proteins that share this feature have now been identified. These findings raise the question of whether or not Frzb-1 is a general inhibitor of signaling by all Wnts. We show that signaling of Wnts -3A, 5A, and 11 is not blocked by Frzb-1, demonstrating that Frzb-1 can discriminate both between the principle functional Wnt classes that have been proposed and within them.
Frzb-1是一种分泌因子，最近研究表明它能抑制Wnt 1和Wnt 8的信号传导。Frzb-1含有一个氨基末端结构域，该结构域与果蝇极性基因卷曲蛋白同源；现已鉴定出其他几种具有此特征的分泌蛋白。这些发现提出了一个问题，即Frzb-1是否是所有Wnt信号传导的通用抑制剂。我们发现Wnt -3A、5A和11的信号传导不会被Frzb-1阻断，这表明Frzb-1既能区分已提出的主要功能性Wnt类别，也能在这些类别内部进行区分。
