Chen Z, Lohman T G, Stini W A, Ritenbaugh C, Aickin M
The University of Arizona, Department of Family and Community Medicine, Tucson 85716, U.S.A.
J Bone Miner Res. 1997 Jan;12(1):144-51. doi: 10.1359/jbmr.1997.12.1.144.
The relative importance of fat and lean tissue mass in determining bone mineral mass among postmenopausal women was examined in this 1-year longitudinal study. Fifty postmenopausal Caucasian women entered the study; 45 of them completed a 1-year follow-up. Dual-energy X-ray absorptiometry was employed for measuring total and regional bone mineral density (BMD) and bone mineral content (BMC), fat tissue mass (FTM), lean tissue mass (LTM), and body weight. Results from linear regression analysis using the cross-sectional data (n = 50) of the study indicated that LTM explained a larger percentage of variation in bone mineral mass than did FTM. FTM and LTM were found to be moderately correlated (r = 0.55); when FTM was entered in the same predicting regression models, LTM was a significant predictor (p < 0.05) of the total and regional BMC, but not BMD. The percent FTM (and inversely %LTM) was correlated with BMD and BMC, but significant correlation was primarily found only for total body BMD (or BMC). Weight was the best predictor of total body BMD and BMC. Longitudinally (n = 45), annual changes in both FTM and weight were significantly associated with annual changes in regional BMD after adjustment for initial bone mineral values (p < 0.05). We conclude that bone mineral mass is more closely related to LTM than to FTM, while annual changes in regional BMD are more closely correlated with changes in FTM in healthy postmenopausal women. Meanwhile, increased body weight is significantly associated with increased bone mineral mass.
在这项为期1年的纵向研究中，研究了脂肪组织和瘦组织质量在绝经后女性骨矿物质质量决定中的相对重要性。50名绝经后白人女性参与了该研究；其中45人完成了1年的随访。采用双能X线吸收法测量全身和局部的骨矿物质密度（BMD）、骨矿物质含量（BMC）、脂肪组织质量（FTM）、瘦组织质量（LTM）和体重。使用该研究的横断面数据（n = 50）进行线性回归分析的结果表明，LTM比FTM解释了更大比例的骨矿物质质量变化。FTM和LTM被发现呈中度相关（r = 0.55）；当FTM纳入相同的预测回归模型时，LTM是全身和局部BMC的显著预测因子（p < 0.05），但不是BMD的显著预测因子。FTM百分比（以及相反的LTM百分比）与BMD和BMC相关，但主要仅在全身BMD（或BMC）中发现显著相关性。体重是全身BMD和BMC的最佳预测因子。纵向来看（n = 45），在调整初始骨矿物质值后，FTM和体重的年度变化与局部BMD的年度变化显著相关（p < 0.05）。我们得出结论，在健康绝经后女性中，骨矿物质质量与LTM的关系比与FTM的关系更密切，而局部BMD的年度变化与FTM的变化更密切相关。同时，体重增加与骨矿物质质量增加显著相关。
