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醋酸环丙孕酮单药治疗晚期前列腺癌

Cyproterone acetate monotherapy in advanced prostatic carcinoma.

作者信息

Kayigil O, Atahan O, Metin A

机构信息

Urologic Clinics of TCDD Ankara Hospital, Turkey.

出版信息

Int Urol Nephrol. 1997;29(2):213-20. doi: 10.1007/BF02551344.

DOI:10.1007/BF02551344
PMID:9241550
Abstract

Cyproterone acetate was given as monotherapy to 18 patients with advanced prostatic carcinoma at a weekly dose of 300 mg. Progression was observed in all of the patients; median time to progression was 35 months and median survival time was 48 months. Partial response, stabilization, progression and exitus rates by years also showed favourable results, as compared with other forms of therapy in advanced prostatic carcinoma.

摘要

醋酸环丙孕酮作为单一疗法给予18例晚期前列腺癌患者,每周剂量为300毫克。所有患者均观察到病情进展;中位进展时间为35个月,中位生存时间为48个月。与晚期前列腺癌的其他治疗形式相比,按年计算的部分缓解、病情稳定、进展和死亡率也显示出良好结果。

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本文引用的文献

1
Antiandrogenic agents as monotherapy in advanced prostatic carcinoma.
Cancer. 1993 Feb 1;71(3 Suppl):1083-8. doi: 10.1002/1097-0142(19930201)71:3+<1083::aid-cncr2820711430>3.0.co;2-1.
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Total androgen suppression: experience from the Scandinavian Prostatic Cancer Group Study No. 2.全雄激素抑制:来自斯堪的纳维亚前列腺癌研究组2号研究的经验。
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Cancer Res. 2021 Dec 1;81(23):5991-6003. doi: 10.1158/0008-5472.CAN-21-0982. Epub 2021 Oct 27.
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Cyproterone acetate enhances TRAIL-induced androgen-independent prostate cancer cell apoptosis via up-regulation of death receptor 5.醋酸环丙孕酮通过上调死亡受体5增强TRAIL诱导的雄激素非依赖性前列腺癌细胞凋亡。
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Luteinizing hormone-releasing hormone agonists in prostate cancer. Elimination of flare reaction by pretreatment with cyproterone acetate and low-dose diethylstilbestrol.前列腺癌中的促黄体生成激素释放激素激动剂。通过醋酸环丙孕酮和低剂量己烯雌酚预处理消除flare反应。
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Treatment of advanced prostatic carcinoma with cyproterone acetate and orchiectomy--5-year follow-up.醋酸环丙孕酮与睾丸切除术治疗晚期前列腺癌——5年随访
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Complete androgen blockade for the treatment of prostate cancer.全雄激素阻断治疗前列腺癌。
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The combination of cyproterone acetate and low dose diethylstilbestrol in the treatment of advanced prostatic carcinoma.
J Urol. 1988 Dec;140(6):1460-5. doi: 10.1016/s0022-5347(17)42073-8.
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Decrease of serum testosterone by cyproterone acetate accompanied by an unexpected increase of calcitonin secretion capacity.醋酸环丙孕酮使血清睾酮水平降低,同时降钙素分泌能力意外增加。
J Urol. 1987 Aug;138(2):324-5. doi: 10.1016/s0022-5347(17)43135-1.
9
Metastatic cancer of the prostate managed with buserelin versus buserelin plus cyproterone acetate.使用布舍瑞林与布舍瑞林加醋酸环丙孕酮治疗转移性前列腺癌。
J Urol. 1987 May;137(5):912-8. doi: 10.1016/s0022-5347(17)44293-5.
10
Cyproterone acetate lead-in prevents initial rise of serum testosterone induced by luteinizing hormone-releasing hormone analogs in the treatment of metastatic carcinoma of the prostate.醋酸环丙孕酮导入可预防促黄体生成素释放激素类似物治疗前列腺转移性癌时血清睾酮的初始升高。
Eur Urol. 1986;12(6):400-2. doi: 10.1159/000472667.