一些新型3-杂环取代色酮的合成及其抗分枝杆菌活性
Synthesis and antimycobacterial activity of some new 3-heterocyclic substituted chromones.
作者信息
Gasparová R, Lácová M, el-Shaaer H M, Odlerová Z
机构信息
Department of Organic Chemistry, Faculty of Natural Sciences, Comenius University, Bratislava, Slovakia.
出版信息
Farmaco. 1997 Apr;52(4):251-3.
PMID:9241831
Abstract
The aldol synthesis of benzimidazole, benzothiazole and benzothiazolium salt derivatives of chromones is described. The structures of the compounds have been proved by elemental analysis and 1H NMR spectra. The antimycobacterial activity of some of the prepared compounds have been tested in vitro against Mycobacterium tuberculosis (H37Rv) and Mycobacterium fortuitum (1021).
摘要
描述了色酮的苯并咪唑、苯并噻唑和苯并噻唑鎓盐衍生物的羟醛缩合反应。通过元素分析和1H NMR光谱证实了这些化合物的结构。对一些制备的化合物针对结核分枝杆菌（H37Rv）和偶然分枝杆菌（1021）进行了体外抗分枝杆菌活性测试。
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