New small-molecule synthetic antimycobacterials.
作者信息
Ballell Lluis, Field Robert A, Duncan Ken, Young Robert J
机构信息
Pharmaceutical Sciences Faculty, Medicinal Chemistry Group, Sorbonnelaan 16, Utrecht University, Utrecht 3584 CA, The Netherlands.
出版信息
Antimicrob Agents Chemother. 2005 Jun;49(6):2153-63. doi: 10.1128/AAC.49.6.2153-2163.2005.
Abstract
摘要
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2
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