Kolchinskaia A Z
Vestn Ross Akad Med Nauk. 1997(5):12-9.
The paper outlines N. N. Sirotinin's concept of the use of stepwise adaptation to diminished inspired air pO2 as a non-drug agent for the prevention and treatment of diseases whose pathogenesis hypoxia and their subsequent rehabilitation play a definite role in. A comprehensive study of the impact of reduced pO2 on man and animals has defined the magnitude of its ambient air changes under which a human being may adapt himself to hypoxia, it characterized five stages of hypoxic hypoxia and concluded that an adaptative process is effective in subcompensated and compensated hypoxia. The paper describes the stepwise adaptation proposed by N. N. Sirotinin to treat diseases chiefly caused by hypoxia and his three identified stages of adaptation-a process considered by N. N. Sirotinin and his pupils as a natural response of the respiratory functional system to the changing magnitude of the usually acting stimuli-reduced arterial blood oxygen and carbon dioxide tension. The mechanisms responsible for the favourable impact of stepwise hypoxic adaptation, which are the basis for its wide use in medicine, occupational hygiene, and sports are presented. Data on the development of N. N. Sirotinin's idea and its medical application in Russia and foreign countries are given.
本文概述了N. N. 西罗蒂宁关于利用逐步适应吸入气中氧分压降低作为一种非药物手段来预防和治疗疾病的概念，这些疾病的发病机制中缺氧及其后续康复起着一定作用。对降低的氧分压对人和动物影响的全面研究确定了环境空气中氧分压变化的幅度，在此幅度下人类可以适应缺氧，描述了低张性缺氧的五个阶段，并得出结论：适应过程在未完全代偿和代偿性缺氧中是有效的。本文描述了N. N. 西罗蒂宁提出的用于治疗主要由缺氧引起的疾病的逐步适应方法，以及他确定的三个适应阶段——N. N. 西罗蒂宁及其学生认为这一过程是呼吸功能系统对通常作用的刺激（动脉血氧和二氧化碳张力降低）变化幅度的自然反应。介绍了逐步低氧适应产生有利影响的机制，这是其在医学、职业卫生和体育中广泛应用的基础。给出了N. N. 西罗蒂宁这一理念在俄罗斯和国外的发展及其医学应用的数据。
