[百日咳博德特氏菌保护性抗原在化学成分固定的培养基上细菌繁殖过程中的表达]

[The expression of Bordetella pertussis protective antigens during bacterial multiplication on a medium with a fixed chemical composition].

作者信息

Shmeleva E I, Mertsalova N U, Sukhinova E V, Kirillova G A, Remova T N, Bazhanova I G, Ozeretskovskaia M N, Britsina M V, Ermolova E V, Zakharova N S

出版信息

Zh Mikrobiol Epidemiol Immunobiol. 1997 Mar-Apr(2):47-50.

PMID:9245141

Abstract

The possibility of obtaining native pertussis preparations with high immunobiological activity has been shown. To obtain such preparations, the use of B. pertussis selected strain, its growth under the conditions of static cultivation in a synthetic culture medium and the use of supernatants with the maximum content of protective antigens with the aim of obtaining protective complexes are necessary.

摘要

已证明获得具有高免疫生物学活性的天然百日咳制剂的可能性。为了获得此类制剂，必须使用百日咳杆菌选定菌株，在合成培养基中静态培养条件下培养该菌株，并使用保护性抗原含量最高的上清液以获得保护性复合物。