经典途径补体激活与副蛋白血症相关
Classical pathway complement activation in association with paraproteinaemia.
作者信息
Naish P F, Collins C, Barratt J
出版信息
Immunology. 1977 Oct;33(4):517-21.
Abstract
Five of twenty-three patients with paraproteinaemia (two IgM, three IgG) have been shown to exhibit marked classical pathway complement activation. The mechanisms of hypocomplementaemia proposed for the five patients are cryoglobulinaemia in one and in vivo immunoglobulin aggregation in the other four. Three further patients had a low C1q and three a low C3 unassociated with any other complement abnormality. No association with any particular IgG subclass or obvious clinical abnormality existed in association with hypocomplementaemia.
摘要
23例副蛋白血症患者（2例IgM型、3例IgG型）中有5例表现出显著的经典途径补体激活。针对这5例患者提出的补体降低机制，1例为冷球蛋白血症，另外4例为体内免疫球蛋白聚集。另有3例患者C1q水平低，3例患者C3水平低，且未伴有其他任何补体异常。补体降低与任何特定的IgG亚类或明显的临床异常均无关联。
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本文引用的文献
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Metabolism of human C1q. Studies in hypogammaglobulinemia, myeloma, and systemic lupus erythematosus.人C1q的代谢。低丙种球蛋白血症、骨髓瘤及系统性红斑狼疮的研究。
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Reduced complement activity in sera of patients with Waldenström's macroglobulinemia.华氏巨球蛋白血症患者血清中补体活性降低。
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Activation of complement by a monoclonal cryoglobulin associated with cold urticaria.与冷性荨麻疹相关的单克隆冷球蛋白激活补体。
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Complement-immunoglobulin relation: deficiency of C'1q associated with impaired immunoglobulin G synthesis.补体-免疫球蛋白关系：C'1q缺乏与免疫球蛋白G合成受损相关。
Science. 1969 Jan 31;163(3866):474-5. doi: 10.1126/science.163.3866.474.
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Biological activities of immunoglobulins of different classes and subclasses.不同类别和亚类免疫球蛋白的生物学活性
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