Naish P F, Collins C, Barratt J
Immunology. 1977 Oct;33(4):517-21.
Five of twenty-three patients with paraproteinaemia (two IgM, three IgG) have been shown to exhibit marked classical pathway complement activation. The mechanisms of hypocomplementaemia proposed for the five patients are cryoglobulinaemia in one and in vivo immunoglobulin aggregation in the other four. Three further patients had a low C1q and three a low C3 unassociated with any other complement abnormality. No association with any particular IgG subclass or obvious clinical abnormality existed in association with hypocomplementaemia.
23例副蛋白血症患者(2例IgM型、3例IgG型)中有5例表现出显著的经典途径补体激活。针对这5例患者提出的补体降低机制,1例为冷球蛋白血症,另外4例为体内免疫球蛋白聚集。另有3例患者C1q水平低,3例患者C3水平低,且未伴有其他任何补体异常。补体降低与任何特定的IgG亚类或明显的临床异常均无关联。