采用标记关联分离卡方检验方法研究胰岛素依赖型糖尿病发病年龄的变异性。
Variable age at onset in insulin-dependent diabetes mellitus, by the marker-association-segregation-chi 2 method.
作者信息
Bonneuil N, Clerget A, Clerget-Darpoux F
机构信息
Institut National des Etudes Démographiques, Paris, France.
出版信息
Am J Hum Genet. 1997 Jul;61(1):223-7. doi: 10.1086/513893.
Abstract
The marker-association-segregation-chi 2 (MASC) method with consideration of age, for nonaffected persons, and of age at onset, for affected persons, was applied to a sample of 308 HLA-typed families. Hazard rates modeling the instantaneous risk of catching the disease were estimated under the exponential distribution and with satisfactory goodness of fit. This class of models shows that the hypothesis of the absence of parental imprinting cannot be rejected for insulin-dependent diabetes mellitus.
摘要
将考虑年龄（针对未患病个体）和发病年龄（针对患病个体）的标记关联分离卡方（MASC）方法应用于308个进行了HLA分型的家庭样本。在指数分布下估计了模拟患病瞬时风险的风险率，拟合优度良好。这类模型表明，胰岛素依赖型糖尿病不存在亲本印记的假设不能被拒绝。
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本文引用的文献
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Testing parental imprinting in insulin-dependent diabetes mellitus by the marker-association-segregation-chi 2 method.运用标记-关联-分离-卡方检验法检测胰岛素依赖型糖尿病中的亲本印记。
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A new method to test genetic models in HLA associated diseases: the MASC method.一种在HLA相关疾病中测试遗传模型的新方法：MASC方法。
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