一种在HLA相关疾病中测试遗传模型的新方法：MASC方法。

A new method to test genetic models in HLA associated diseases: the MASC method.

作者信息

Clerget-Darpoux F, Babron M C, Prum B, Lathrop G M, Deschamps I, Hors J

机构信息

Unité de Recherches de Génétique Epidémiologique (I.N.S.E.R.M. U. 155), Château de Longchamp, Bois de Boulogne, Paris, France.

出版信息

Ann Hum Genet. 1988 Jul;52(3):247-58. doi: 10.1111/j.1469-1809.1988.tb01102.x.

DOI:10.1111/j.1469-1809.1988.tb01102.x

PMID:3074732

Abstract

We propose a new method to analyse data on HLA associated diseases. The method uses the simultaneous information on the marker associations and segregation with the disease. It may also take into account the differential risk of being affected for specific relatives of a patient as well as the differential HLA haplotype sharing according to the marker genotype of the patient. It is based on the principle of minimization of a sum of independent chi-squares. It allows us to test the goodness-of-fit of various models in an easy and economical way. The method is applied to a sample of 269 French IDDM patients and their relatives leading to the rejection of models with one locus closely linked to HLA with two and three alleles.

摘要

我们提出了一种分析HLA相关疾病数据的新方法。该方法利用标记关联和疾病分离的同时信息。它还可以考虑患者特定亲属受影响的不同风险以及根据患者的标记基因型不同的HLA单倍型共享情况。它基于最小化独立卡方和的原则。它使我们能够以简单且经济的方式检验各种模型的拟合优度。该方法应用于269名法国IDDM患者及其亲属的样本，导致与具有两个和三个等位基因且与HLA紧密连锁的一个位点的模型被拒绝。