Squire L R, Zola S M
Veterans Affairs Medical Center, San Diego, California, USA.
Cold Spring Harb Symp Quant Biol. 1996;61:185-95.
The cognitive and neuroanatomical work described here should be viewed as a first step in analyzing how the brain has organized its memory functions, which can open the door to more detailed neurobiological analysis. With respect to declarative memory, it should soon be possible to study representations directly in neocortex with the technique of single-cell recording, to observe directly the development of neuronal plasticity important for declarative memory, and to determine how the medial temporal lobe interacts with neocortex during learning, consolidation, and retrieval. In this regard, the paradigms developed by Miyashita and his colleagues appear to hold particular promise (Sakai and Miyashita 1991; Higuchi and Miyashita 1996). With respect to nondeclarative memory, it is now possible to identify particular brain systems that are essential for particular kinds of memory. An important next step will be to determine whether these systems are essential for the acquisition, storage, or expression of memory, and to identify exactly where the synaptic changes occur that support each kind of memory.
此处所描述的认知和神经解剖学研究工作应被视为分析大脑如何组织其记忆功能的第一步，这可能为更详细的神经生物学分析打开大门。关于陈述性记忆，很快就有可能利用单细胞记录技术直接在新皮层中研究表征，直接观察对陈述性记忆至关重要的神经元可塑性的发展，并确定内侧颞叶在学习、巩固和检索过程中如何与新皮层相互作用。在这方面，宫下及其同事开发的范式似乎特别有前景（酒井和宫下，1991年；东口和宫下，1996年）。关于非陈述性记忆，现在有可能确定对特定类型记忆至关重要的特定脑系统。接下来重要的一步将是确定这些系统对于记忆的获取、存储或表达是否必不可少，并准确确定支持每种记忆的突触变化发生在哪里。
