迟发型超敏反应和对微生物疫苗的细胞免疫调节：环磷酰胺对兔热病疫苗免疫反应的影响。

Modulation of delayed-type hypersensitivity and cellular immunity to microbial vaccines: effects of cyclophosphamide on the immune response to tularemia vaccine.

作者信息

Ascher M S, Parker D, Turk J L

出版信息

Infect Immun. 1977 Nov;18(2):318-23. doi: 10.1128/iai.18.2.318-323.1977.

DOI:10.1128/iai.18.2.318-323.1977

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC421233/

Abstract

Treatment of guinea pigs with cyclophosphamide before immunization with killed tularemia vaccine in Freund incomplete adjuvant produced a prolongation and intensification of delayed-type hypersensitivity and in vitro lymphocyte transformation reactions to tularemia antigen. Such reactions resemble those ordinarily associated with the administration of live tularemia vaccine, killed vaccine in Freund complete adjuvant, or recovery from natural infection. The immunopotentiation lasted longer than that seen previously in other antigenic systems with this drug and was dependent on the dose of vaccine used. More intense delayed skin reactivity could be transferred into normal controls by cells from immunized donors pretreated with cyclophosphamide than by cells from immunized donors that were not pretreated.

摘要

在用弗氏不完全佐剂中的灭活土拉菌疫苗免疫豚鼠之前，用环磷酰胺对其进行处理，可使迟发型超敏反应以及对土拉菌抗原的体外淋巴细胞转化反应延长并增强。此类反应类似于通常与接种活土拉菌疫苗、弗氏完全佐剂中的灭活疫苗或从自然感染中恢复相关的反应。这种免疫增强作用持续的时间比之前在其他抗原系统中使用该药物时观察到的更长，并且取决于所用疫苗的剂量。与未用环磷酰胺预处理的免疫供体的细胞相比，用环磷酰胺预处理的免疫供体的细胞能将更强的迟发性皮肤反应性转移到正常对照中。

相似文献

1

Modulation of delayed-type hypersensitivity and cellular immunity to microbial vaccines: effects of cyclophosphamide on the immune response to tularemia vaccine.迟发型超敏反应和对微生物疫苗的细胞免疫调节：环磷酰胺对兔热病疫苗免疫反应的影响。

Infect Immun. 1977 Nov;18(2):318-23. doi: 10.1128/iai.18.2.318-323.1977.

2

Mechanisms of protective immunogenicity of microbial vaccines: effects of cyclophosphamide pretreatment in Venezuelan encephalitis, Q fever and tularaemia.微生物疫苗的保护性免疫原性机制：环磷酰胺预处理对委内瑞拉马脑炎、Q热和兔热病的影响。

Clin Exp Immunol. 1980 Aug;41(2):225-36.

3

[ROLE OF VARIOUS ANTIGENIC PREPARATIONS OF FRANCISELLA TULARENSIS IN FORMATION OF ALLERGY REACTION IN HUMANS AND ANIMALS].[土拉热弗朗西斯菌的各种抗原制剂在人和动物过敏反应形成中的作用]

Zh Mikrobiol Epidemiol Immunobiol. 2016 Jan-Feb(1):22-9.

4

Infection-immunity in tularemia: specificity of cellular immunity.兔热病中的感染免疫：细胞免疫的特异性

Infect Immun. 1972 Mar;5(3):311-8. doi: 10.1128/iai.5.3.311-318.1972.

5

Intranasal administration of a two-dose adjuvanted multi-antigen TMV-subunit conjugate vaccine fully protects mice against Francisella tularensis LVS challenge.鼻腔内给予两剂佐剂多抗原 TMV-亚单位缀合疫苗可完全保护小鼠免受兔热病杆菌 LVS 挑战。

PLoS One. 2018 Apr 23;13(4):e0194614. doi: 10.1371/journal.pone.0194614. eCollection 2018.

6

[Effect of the combined use of rifampicin and a low-molecular immunomodulator of natural origin on the primary immune response to the antigens of a tularemia vaccinal strain].[利福平与天然来源低分子免疫调节剂联合使用对土拉菌病疫苗株抗原的初次免疫应答的影响]

Antibiot Med Biotekhnol. 1985 Oct;30(10):760-5.

7

[Resistance to the Venezuelan equine encephalomyelitis virus in immunization with live tularemia vaccine].[用活兔热病疫苗免疫时对委内瑞拉马脑炎病毒的抗性]

Zh Mikrobiol Epidemiol Immunobiol. 1982 Sep(9):68-72.

8

Oral immunization of mice with the live vaccine strain (LVS) of Francisella tularensis protects mice against respiratory challenge with virulent type A F. tularensis.用土拉弗朗西斯菌活疫苗株（LVS）对小鼠进行口服免疫，可保护小鼠免受强毒A型土拉弗朗西斯菌的呼吸道攻击。

Vaccine. 2007 May 10;25(19):3781-91. doi: 10.1016/j.vaccine.2007.02.014. Epub 2007 Feb 26.

9

[The nonspecific protection of guinea pigs immunized with a live tularemia vaccine against lung infection by Legionella pneumophila].[用活兔热病疫苗免疫的豚鼠对嗜肺军团菌肺部感染的非特异性保护作用]

Zh Mikrobiol Epidemiol Immunobiol. 1991 Aug(8):50-1.

10

A live avirulent mutant Legionella pneumophila vaccine induces protective immunity against lethal aerosol challenge.一种活的无毒力突变型嗜肺军团菌疫苗可诱导针对致死性气溶胶攻击的保护性免疫。

J Clin Invest. 1989 Mar;83(3):810-5. doi: 10.1172/JCI113962.

引用本文的文献

1

Mechanisms of protective immunogenicity of microbial vaccines: effects of cyclophosphamide pretreatment in Venezuelan encephalitis, Q fever and tularaemia.微生物疫苗的保护性免疫原性机制：环磷酰胺预处理对委内瑞拉马脑炎、Q热和兔热病的影响。

Clin Exp Immunol. 1980 Aug;41(2):225-36.

2

Experimental model for dermal granulomatous hypersensitivity in Q fever.Q热皮肤肉芽肿超敏反应的实验模型

Infect Immun. 1983 Jan;39(1):388-93. doi: 10.1128/iai.39.1.388-393.1983.

3

Experimental rabies in skunks: effects of immunosuppression induced by cyclophosphamide.臭鼬的实验性狂犬病：环磷酰胺诱导免疫抑制的影响

Can J Comp Med. 1984 Jan;48(1):72-7.

4

Effect of cyclophosphamide on Toxoplasma gondii infection: reversal of the effect by passive immunization.环磷酰胺对刚地弓形虫感染的影响：被动免疫对该影响的逆转作用。

Clin Exp Immunol. 1978 Sep;33(3):389-94.

5

Relation between delayed hypersensitivity and cell-mediated immunity.迟发型超敏反应与细胞介导免疫之间的关系。

J R Soc Med. 1979 Apr;72(4):243-5. doi: 10.1177/014107687907200401.

6

The cellular control of delayed hypersensitivity to Staphylococcus aureus in mice.小鼠对金黄色葡萄球菌迟发型超敏反应的细胞控制

Immunology. 1979 Sep;38(1):103-8.

本文引用的文献

1

Vaccine Prophylaxis against Tularemia in Man.人类兔热病的疫苗预防

Am J Public Health Nations Health. 1942 Oct;32(10):1131-45. doi: 10.2105/ajph.32.10.1131.

2

Studies on tularemia. V. Immunization of man.兔热病研究。五、人体免疫

J Immunol. 1950 Oct;65(4):425-35.

3

Studies on the relationship of delayed hypersensitivity to immunity in tularemia.兔热病中迟发型超敏反应与免疫关系的研究。

J Immunol. 1963 Feb;90:209-16.

4

Prophylactic effectiveness of live and killed tularemia vaccines. I. Production of vaccine and evaluation in the white mouse and guinea pig.活疫苗和灭活土拉菌疫苗的预防效果。I. 疫苗的制备及在小白鼠和豚鼠身上的评估。

J Immunol. 1961 Oct;87:415-25.

5

Tularemia vaccine study. I. Intracutaneous challenge.兔热病疫苗研究。一、皮内激发试验。

Arch Intern Med. 1961 May;107:689-701. doi: 10.1001/archinte.1961.03620050055006.

6

Tularemia vaccine study. II. Respiratory challenge.兔热病疫苗研究。II. 呼吸道激发试验。

Arch Intern Med. 1961 May;107:702-14. doi: 10.1001/archinte.1961.03620050068007.

7

Parity and optical activity.宇称与旋光性。

Nature. 1972 Jul 7;238(5358):17-9. doi: 10.1038/238017a0.

8

The tularemia skin test. 325 skin tests in 210 persons: serologic correlation and review of the literature.兔热病皮肤试验。210人进行了325次皮肤试验：血清学相关性及文献综述。

Ann Intern Med. 1971 Mar;74(3):336-43. doi: 10.7326/0003-4819-74-3-336.

9

Correlates to increased lethality of attenuated Venezuelan encephalitis virus vaccine for immunosuppressed hamsters.与减毒委内瑞拉脑炎病毒疫苗对免疫抑制仓鼠致死率增加相关。

Infect Immun. 1974 May;9(5):924-30. doi: 10.1128/iai.9.5.924-930.1974.

10

Immunopathogenesis of acute central nervous system disease produced by lymphocytic choriomeningitis virus. I. Cyclophosphamide-mediated induction by the virus-carrier state in adult mice.淋巴细胞性脉络丛脑膜炎病毒所致急性中枢神经系统疾病的免疫发病机制。I. 环磷酰胺介导成年小鼠病毒携带状态诱导发病

J Exp Med. 1972 Apr 1;135(4):860-73. doi: 10.1084/jem.135.4.860.

文献AI研究员

20分钟写一篇综述，助力文献阅读效率提升50倍。

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

文档翻译

学术文献翻译模型，支持多种主流文档格式。