Bisht K S, Uma Devi P
Department of Radiobiology, Kasturba Medical College, Karnataka, India.
Indian J Exp Biol. 1996 Dec;34(12):1183-9.
There are critical maximum temperatures above which irreversible damage occurs in cells and tissues. Exposure to high temperature, referred to as hyperthermia (HT), can result in cell death, tissue damage or even death of the organism. Clinical application of HT as a primary treatment or as an adjuvant to radio-/chemo- therapy of cancer is based on its ability to cause localized tumor tissue damage. Experimental data provide HT with a strong biological rationale. Early clinical experience suggested that HT will become an important modality as an adjuvant to radiotherapy in the treatment of human malignancies, but its application is currently limited to mainly superficial tumors. Its full realization as a treatment modality for cancer therapy awaits further laboratory investigations as well as controlled clinical trials. A better understanding of the biological mechanisms of its action, interaction with chemotherapeutic drugs and radiation damage, role of tumor microenvironment such as oxygen status and pH of tumors, and kinetics of thermotolerance can lead to refinement in its clinical implementation. The present review attempts to analyse the published literature during the last one and half decades.
存在一些临界最高温度，超过这些温度，细胞和组织就会发生不可逆损伤。暴露于高温下，即热疗（HT），可导致细胞死亡、组织损伤甚至生物体死亡。热疗作为癌症的主要治疗方法或放化疗辅助手段的临床应用，是基于其导致局部肿瘤组织损伤的能力。实验数据为热疗提供了强有力的生物学依据。早期临床经验表明，热疗将成为治疗人类恶性肿瘤放疗辅助的重要手段，但其应用目前主要限于浅表肿瘤。热疗作为癌症治疗的一种方式得到充分实现，尚有待进一步的实验室研究以及对照临床试验。更好地理解其作用的生物学机制、与化疗药物的相互作用和辐射损伤、肿瘤微环境如肿瘤的氧状态和pH值的作用以及热耐受动力学，可使热疗的临床应用更加完善。本综述试图分析过去十五年间已发表的文献。
