Robins H I
Cancer Res. 1984 Oct;44(10 Suppl):4878s-4883s.
Modern cancer therapy has included surgery, radiotherapy, chemotherapy, and most recently, immunotherapy and hyperthermia. As neoplastic diseases are heterogeneous in regard to each cell subpopulation's response to a given therapy, a multimodality treatment approach should enhance the changes of all subpopulations of cells being killed. The potential of hyperthermia as a treatment modality for cancer was first predicted following observations that several types of cancer cells were more sensitive to temperatures in excess of 41 degrees than were their normal cell counterparts. Beyond these studies, there now is preclinical evidence as well as the clinical suggestion that hyperthermia potentiates radiation and/or drugs for the treatment of cancer. As most cancers refractory to conventional therapy are systemic diseases, the proposal that whole-body hyperthermia in combination with other therapies be used to treat metastatic disease is an inherently attractive approach. The basis and the practicality of this proposal is presented here with suggestions for its application to current preclinical and clinical research.
现代癌症治疗方法包括手术、放疗、化疗，以及最近出现的免疫疗法和热疗。由于肿瘤疾病在每个细胞亚群对特定治疗的反应方面具有异质性，多模态治疗方法应能提高所有细胞亚群被杀死的几率。热疗作为一种癌症治疗方式的潜力最初是在观察到几种癌细胞比其正常细胞对应物对超过41摄氏度的温度更敏感后被预测出来的。除了这些研究之外，现在有临床前证据以及临床迹象表明，热疗可增强放疗和/或药物治疗癌症的效果。由于大多数对传统治疗难治的癌症是全身性疾病，因此将全身热疗与其他疗法联合用于治疗转移性疾病的提议本质上是一种有吸引力的方法。本文介绍了该提议的依据和实用性，并对其应用于当前临床前和临床研究提出了建议。
