Effect of CPT-11 on lipid peroxide level in mouse tissues.
作者信息
Sadzuka Y, Hirota S
机构信息
School of Pharmaceutical Sciences, University of Shizuoka.
出版信息
Jpn J Cancer Res. 1997 May;88(5):512-6. doi: 10.1111/j.1349-7006.1997.tb00411.x.
Abstract
We examined the effects of CPT-11 on lipid peroxide level and glutathione peroxidase (GSHpx) activity as indices of the toxicity of this antitumor agent in mouse and rat tissues. After CPT-11 (100 mg/kg, i.p.) administration, the lipid peroxide level in the heart increased 1.5 fold (mice) and 1.3 fold (rats) over the control levels. GSHpx activity decreased to 64% of the control. In the lung, the lipid peroxide level and GSHpx activity increased 2.5 fold and decreased to 74% after CPT-11 administration, respectively, compared with the control values. These results suggested that CPT-11 may cause cardiotoxicity and pulmotoxicity. In rat bone marrow, the lipid peroxide level increased on the 2nd day after CPT-11 injection. We suggest that in both single and combination treatment with CPT-11, the possibility of side effects should be taken into consideration.
摘要
相似文献
1
Effect of CPT-11 on lipid peroxide level in mouse tissues.
Jpn J Cancer Res. 1997 May;88(5):512-6. doi: 10.1111/j.1349-7006.1997.tb00411.x.
2
Effect of seasonal variation on lipid peroxide level and glutathione peroxidase activity in the mouse before and after adriamycin administration.
Toxicol Lett. 1992 Jun;61(1):49-56. doi: 10.1016/0378-4274(92)90062-o.
3
Protective effect of flavonoids on doxorubicin-induced cardiotoxicity.
Toxicol Lett. 1997 Jun 16;92(1):1-7. doi: 10.1016/s0378-4274(97)00028-3.
4
α-Tocopherol mediated amelioration of camptothecin-induced free radical damage to avert cardiotoxicities.
Hum Exp Toxicol. 2015 Apr;34(4):380-9. doi: 10.1177/0960327114533577. Epub 2014 Oct 10.
5
Cell kinetics-dependent antitumor effect of irinotecan hydrochloride induced by the synchronizing effect of hydroxyurea: cell kinetics and dosing time.
Life Sci. 2003 Jan 24;72(10):1183-97. doi: 10.1016/s0024-3205(02)02363-9.
6
Alleviation of side effects induced by irinotecan hydrochloride (CPT-11) in rats by intravenous infusion.
Cancer Chemother Pharmacol. 2003 Nov;52(5):349-60. doi: 10.1007/s00280-003-0682-0. Epub 2003 Aug 6.
7
Chronic hydrogen peroxide intake and peroxide metabolizing enzyme activities in some tissues of mice and rats.
Experientia. 1986 Sep 15;42(9):1018-20. doi: 10.1007/BF01940713.
8
Effects of diethylhydroxylamine on hepatic microsomal lipid peroxidation and glutathione S-transferases.
J Toxicol Environ Health. 1985;15(3-4):467-75. doi: 10.1080/15287398509530673.
9
[Biological specificity of the neonate and infant heart, with reference to selenium and glutathione peroxidase--the study to clarify the cause of vulnerability of neonate and infant heart].
Nihon Kyobu Geka Gakkai Zasshi. 1991 Jul;39(7):1011-6.
10
A mechanistic study on reduced toxicity of irinotecan by coadministered thalidomide, a tumor necrosis factor-alpha inhibitor.
J Pharmacol Exp Ther. 2006 Oct;319(1):82-104. doi: 10.1124/jpet.106.103606. Epub 2006 Jun 30.
引用本文的文献
1
Irinotecan and Δ⁸-Tetrahydrocannabinol Interactions in Rat Liver: A Preliminary Evaluation Using Biochemical and Genotoxicity Markers.
Molecules. 2018 Jun 1;23(6):1332. doi: 10.3390/molecules23061332.
2
Curcumin protects heart tissue against irinotecan-induced damage in terms of cytokine level alterations, oxidative stress, and histological damage in rats.
Naunyn Schmiedebergs Arch Pharmacol. 2018 Aug;391(8):783-791. doi: 10.1007/s00210-018-1495-3. Epub 2018 May 2.
3
Significance of nuclear glutathione S-transferase pi in resistance to anti-cancer drugs.
Jpn J Cancer Res. 2002 Sep;93(9):1047-56. doi: 10.1111/j.1349-7006.2002.tb02482.x.
4
Fish oil supplementation enhanced CPT-11 (irinotecan) efficacy against MCF7 breast carcinoma xenografts and ameliorated intestinal side-effects.
Br J Cancer. 1999 Oct;81(3):440-8. doi: 10.1038/sj.bjc.6690713.
本文引用的文献
1
Protein measurement with the Folin phenol reagent.
J Biol Chem. 1951 Nov;193(1):265-75.
2
Camptothecins: from bench research to hospital wards.
Cancer Res. 1994 Mar 15;54(6):1431-9.
3
[Effect of chemotherapy using irinotecan (CPT-11) against recurrent colorectal cancer].
Gan To Kagaku Ryoho. 1995 Jan;22(1):93-7.
4
A pharmacokinetic and pharmacodynamic analysis of CPT-11 and its active metabolite SN-38.
Jpn J Cancer Res. 1995 Jan;86(1):101-10. doi: 10.1111/j.1349-7006.1995.tb02994.x.
5
Micro-determination of lipoperoxide in the mouse myocardium by thiobarbituric acid fluorophotometry.
Chem Pharm Bull (Tokyo). 1981 Oct;29(10):2910-4. doi: 10.1248/cpb.29.2910.
6
7
Change of lipid peroxide levels in mouse organs after adriamycin administration.
Chem Pharm Bull (Tokyo). 1983 May;31(5):1714-8. doi: 10.1248/cpb.31.1714.
8
Effect of dietary selenium on erythrocyte and liver glutathione peroxidase in the rat.
J Nutr. 1974 May;104(5):580-7. doi: 10.1093/jn/104.5.580.
9
DNA topoisomerase poisons as antitumor drugs.
Annu Rev Biochem. 1989;58:351-75. doi: 10.1146/annurev.bi.58.070189.002031.
10
Effect of adriamycin on the activities of superoxide dismutase, glutathione peroxidase and catalase in tissues of mice.
Jpn J Cancer Res. 1989 Jan;80(1):89-94. doi: 10.1111/j.1349-7006.1989.tb02250.x.
Zotero 插件