CPT-11对小鼠组织中脂质过氧化物水平的影响。
Effect of CPT-11 on lipid peroxide level in mouse tissues.
作者信息
Sadzuka Y, Hirota S
机构信息
School of Pharmaceutical Sciences, University of Shizuoka.
出版信息
Jpn J Cancer Res. 1997 May;88(5):512-6. doi: 10.1111/j.1349-7006.1997.tb00411.x.
We examined the effects of CPT-11 on lipid peroxide level and glutathione peroxidase (GSHpx) activity as indices of the toxicity of this antitumor agent in mouse and rat tissues. After CPT-11 (100 mg/kg, i.p.) administration, the lipid peroxide level in the heart increased 1.5 fold (mice) and 1.3 fold (rats) over the control levels. GSHpx activity decreased to 64% of the control. In the lung, the lipid peroxide level and GSHpx activity increased 2.5 fold and decreased to 74% after CPT-11 administration, respectively, compared with the control values. These results suggested that CPT-11 may cause cardiotoxicity and pulmotoxicity. In rat bone marrow, the lipid peroxide level increased on the 2nd day after CPT-11 injection. We suggest that in both single and combination treatment with CPT-11, the possibility of side effects should be taken into consideration.
我们检测了CPT - 11对脂质过氧化物水平和谷胱甘肽过氧化物酶（GSHpx）活性的影响，以此作为该抗肿瘤药物在小鼠和大鼠组织中毒性的指标。腹腔注射CPT - 11（100 mg/kg）后，心脏中的脂质过氧化物水平比对照水平增加了1.5倍（小鼠）和1.3倍（大鼠）。GSHpx活性降至对照的64%。在肺中，与对照值相比，CPT - 11给药后脂质过氧化物水平增加了2.5倍，GSHpx活性降至74%。这些结果表明CPT - 11可能会导致心脏毒性和肺毒性。在大鼠骨髓中，CPT - 11注射后第2天脂质过氧化物水平升高。我们建议，在CPT - 11的单药治疗和联合治疗中，都应考虑到副作用的可能性。
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