小鼠和大鼠某些组织中过氧化氢的长期摄入及过氧化物代谢酶活性
Chronic hydrogen peroxide intake and peroxide metabolizing enzyme activities in some tissues of mice and rats.
作者信息
Kihlström M, Salminen A, Vihko V
出版信息
Experientia. 1986 Sep 15;42(9):1018-20. doi: 10.1007/BF01940713.
Chronic daily intake of 0.5% H2O2 in drinking water decreased Se-dependent glutathione peroxidase (Se-GSHPx) activity in rat skeletal muscle, kidney and liver. Non-Se GSHPx activity decreased in kidney. Deprivation of drinking water decreased Se-GSHPx activity in kidney and non-Se GSHPx activity in kidney and liver. H2O2 intake decreased activity of catalase in rat skeletal muscle. H2O2 intake or water deprivation caused no changes in these enzyme activities in mice.
每日在饮用水中添加0.5%的过氧化氢，连续长期摄入，会降低大鼠骨骼肌、肾脏和肝脏中硒依赖性谷胱甘肽过氧化物酶（Se-GSHPx）的活性。肾脏中的非硒谷胱甘肽过氧化物酶（Non-Se GSHPx）活性降低。断水会降低肾脏中Se-GSHPx的活性以及肾脏和肝脏中非硒谷胱甘肽过氧化物酶的活性。摄入过氧化氢会降低大鼠骨骼肌中过氧化氢酶的活性。摄入过氧化氢或断水对小鼠这些酶的活性没有影响。
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