Cooney T, Sweeney E C, Luke D
J Clin Pathol. 1979 Nov;32(11):1100-9. doi: 10.1136/jcp.32.11.1100.
Twenty-two pulmonary carcinoid tumours (18 central, 4 peripheral) were seen in this department over an 11-year period. The majority of the tumours displayed a mixed pattern on microscopic examination, and cell-nest formation was a prominent feature in sixteen. The findings are at variance with the results of a similar series reported from Japan and suggest that there is regional variation in the tumour pattern of pulmonary carcinoids. Various aspects of the histopathology are discussed, and a causal relationship between ossification of bronchial cartilage in these tumours and locally produced calcitonin is postulated.
在11年期间，该科室共发现22例肺类癌肿瘤（18例中央型，4例周围型）。大多数肿瘤在显微镜检查时呈现混合模式，16例中细胞巢形成是一个显著特征。这些发现与日本报道的类似系列结果不同，提示肺类癌的肿瘤模式存在区域差异。本文讨论了组织病理学的各个方面，并推测这些肿瘤中支气管软骨骨化与局部产生的降钙素之间存在因果关系。
