头孢唑氟与其他胃肠外头孢菌素的体外研究。

In vitro studies with cefazaflur and other parenteral cephalosporins.

作者信息

Actor P, Guarini J R, Uri J, Bartus H F, Zajac I, Weisbach J A

出版信息

J Antibiot (Tokyo). 1977 Sep;30(9):730-5. doi: 10.7164/antibiotics.30.730.

DOI:10.7164/antibiotics.30.730

Abstract

Cefazaflur has a broad-spectrum of in vitro antibacterial activity equal to or greater than that of the commercially-available cephalosporins. In addition, cefazaflur has activity against isolates of Enterobacter, Citrobacter and indole-positive Proteus; however, this activity decreased markedly when the MIC determinations were carried out with a large inoculum size. A similar inoculum effect was observed with cefamandole, however, cefoxitin's activity was relatively unchanged at increased inoculum sizes. Human serum had a relatively small effect on the in vitro activity of cefazaflur.

摘要

头孢扎氟具有广谱的体外抗菌活性，等同于或强于市售头孢菌素。此外，头孢扎氟对阴沟肠杆菌、柠檬酸杆菌和吲哚阳性变形杆菌的分离株具有活性；然而，当使用大量接种量进行最低抑菌浓度（MIC）测定时，这种活性显著降低。头孢孟多也观察到类似的接种量效应，不过，头孢西丁在接种量增加时其活性相对不变。人血清对头孢扎氟的体外活性影响相对较小。