头孢扎氟的体外活性及β-内酰胺酶稳定性与β-内酰胺酶稳定型头孢菌素的比较。
In vitro activity and beta-lactamase stability of cefazaflur compared with those of beta-lactamase-stable cephalosporins.
作者信息
Aswapokee N, Neu H C
出版信息
Antimicrob Agents Chemother. 1979 Mar;15(3):444-6. doi: 10.1128/AAC.15.3.444.
Abstract
The in vitro activity of cefazaflur, a parenteral cephalosporin, was determined against 590 clinical isolates. Cefazaflur inhibited the majority of gram-positive cocci at concentrations below 1 mug/ml except for enterococci. The agent was as active as cefamandole or cefoxitin against most Escherichia coli, Klebsiella pneumoniae, and Proteus mirabilis. Although it inhibited a number of strains of Enterobacter, indole-positive Proteus, and Serratia resistant to cephalothin, it was much less active against these organisms than were cefamandole or cefoxitin.
摘要
对一种肠道外头孢菌素头孢扎氟的体外活性进行了针对590株临床分离菌的测定。除肠球菌外，头孢扎氟在浓度低于1微克/毫升时能抑制大多数革兰氏阳性球菌。该药物对大多数大肠杆菌、肺炎克雷伯菌和奇异变形杆菌的活性与头孢孟多或头孢西丁相当。虽然它能抑制一些对头孢噻吩耐药的阴沟肠杆菌、吲哚阳性变形杆菌和沙雷菌菌株，但对这些菌的活性远低于头孢孟多或头孢西丁。
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