Wilson W R, Bouza E, Lode H, Mouton Y
Division of Infectious Diseases, Mayo Clinic, Rochester, MN 55905, USA.
J Chemother. 1997 May;9 Suppl 2:5-18.
The use of the broad-spectrum cephalosporin, cefotaxime, in internal medicine is well-established, particularly in the treatment of moderately severe to severe community- and hospital-acquired infections. It is particularly useful for infections of the lower respiratory tract, urinary and biliary systems, skin and soft tissue, and in serious conditions, such as meningitis, particularly in pediatric patients. Knowledge of the pharmacokinetic and pharmacodynamic properties of cefotaxime supports the view that low dose (1-2 g), low frequency (12-hourly) dosage regimens are applicable to many mild-to-moderately severe infections, including community-acquired pneumonia, caused by susceptible organisms.
广谱头孢菌素头孢噻肟在内科中的应用已得到充分确立，尤其在治疗中度严重至重度社区获得性和医院获得性感染方面。它对下呼吸道、泌尿系统和胆道系统、皮肤和软组织感染特别有用，在严重病症如脑膜炎（尤其是儿科患者）中也很有用。头孢噻肟的药代动力学和药效学特性知识支持这样一种观点，即低剂量（1 - 2克）、低频率（每12小时一次）给药方案适用于许多由易感病原体引起的轻度至中度严重感染，包括社区获得性肺炎。
