Blom H M, Van Rijswijk J B, Garrelds I M, Mulder P G, Timmermans T, Gerth van Wijk R
Department of Oto-Rhino-Laryngology, Erasmus University Rotterdam and Dijkzigt Hospital, the Netherlands.
Clin Exp Allergy. 1997 Jul;27(7):796-801. doi: 10.1046/j.1365-2222.1997.670842.x.
Several authors described capsaicin, the pungent substance in red pepper, as an efficacious therapy for non-allergic non-infectious perennial rhinitis (NANIPER). Repeated capsaicin application induces peptide depletion and specific degeneration of the unmyelinated sensory C-fibres in the nasal mucosa.
We performed a placebo-controlled (NaCl 0.9%) study with 25 NANIPER patients. Daily record charts and visual analogue scales (VAS) were used for clinical evaluation. Nasal lavages were obtained before, during, and after treatment.
There was a significant and long-term reduction in the VAS scores in the capsaicin group. No significant difference was found between the placebo and capsaicin treated groups for the mean group concentrations of leukotriene (LT) C4/D4/E4, prostaglandin D2 (PGD2), and tryptase. The levels of mast cell mediators, tryptase and PGD2, and leukotrienes, mediators derived from a variety of inflammatory cells, were low at baseline and comparable with levels observed in nasal lavages obtained from normals.
As involvement of inflammation could not be demonstrated, it is not surprising that capsaicin has no effect on inflammatory mediators. This suggests that inflammatory cells do not play a major part in the pathogenesis of NANIPER.
几位作者将红辣椒中的辛辣物质辣椒素描述为治疗非过敏性非感染性常年性鼻炎（NANIPER）的有效疗法。反复应用辣椒素会导致鼻黏膜中无髓鞘感觉C纤维的肽耗竭和特定变性。
我们对25例NANIPER患者进行了一项安慰剂对照（0.9%氯化钠）研究。使用每日记录图表和视觉模拟量表（VAS）进行临床评估。在治疗前、治疗期间和治疗后获取鼻洗液。
辣椒素组的VAS评分有显著且长期的降低。在白三烯（LT）C4/D4/E4、前列腺素D2（PGD2）和类胰蛋白酶的平均组浓度方面，安慰剂组和辣椒素治疗组之间未发现显著差异。肥大细胞介质类胰蛋白酶和PGD2以及白三烯（多种炎症细胞衍生的介质）的水平在基线时较低，与从正常人获取的鼻洗液中观察到的水平相当。
由于无法证明炎症的参与，辣椒素对炎症介质没有影响也就不足为奇了。这表明炎症细胞在NANIPER的发病机制中不起主要作用。
