al-Wakeel J S, Mitwalli A H, Huraib S, al-Mohaya S, Abu-Aisha H, Chaudhary A R, al-Majed S A, Memon N
King Khalid University Hospital, Riyadh, Saudi Arabia.
Nephrol Dial Transplant. 1997 Jul;12(7):1420-4. doi: 10.1093/ndt/12.7.1420.
High serum fluoride (F-) in patients with chronic renal failure (CRF) and end-stage renal disease (ESRD) is associated with risk of renal osteodystrophy and other bone changes. This study was done to determine F- in normal healthy controls and patients with ESRD on haemodialysis (HD) or peritoneal dialysis (PD). Seventeen healthy controls (12 males, 5 females) and 39 ESRD patients on dialysis (17 males, 22 females) were recruited in the study in a community with 47.4 +/- 3.28 microM/l (range 44-51 microM/l) of F- content in drinking water. Control subjects showed a mean serum F- concentration of 1.08 +/- 0.350 microM/l. Males in control group showed slightly higher F- levels (1.15 +/- 0.334, range 0.55-1.9 microM/l) than females (0.92 +/- 0.370, range 0.6-1.5 microM/l). Mean serum F- concentration did not correlate significantly with age and sex among control subjects, whereas such correlation was observed in patients with ESRD on dialysis. Mean serum F- concentration was significantly higher in patients on dialysis (2.67 +/- 1.09, range 0.8-5.2 microM/l) than normal controls. When grouped according to sex, the mean serum F- concentration in males (3.05 +/- 1.04, range 1.8-5.2 microM/l) was significantly higher than females (2.38 +/- 1.08, range 0.8-5.2 microM/l). When patients were grouped according to age, it was observed that F- concentration was significantly higher in patients with age groups 21-70 (2.86 +/- 1.05) than those with age group 13-20 years (1.42 +/- 0.531). Thus F- concentration correlated with age and sex, being higher in males and above 20 years. Despite appreciable clearance of F- (39-90%) across the peritoneum, patients on CAPD showed higher serum F- concentration than those on HD (3.1 +/- 1.97 vs 2.5 +/- 1.137 microM/l). Of the total 39 patients on dialysis 39% had their serum F- concentration above 3.0 microM/l, posing the risk of renal osteodystrophy.
慢性肾衰竭（CRF）和终末期肾病（ESRD）患者血清氟化物（F-）水平升高与肾性骨营养不良及其他骨骼变化风险相关。本研究旨在测定正常健康对照者以及接受血液透析（HD）或腹膜透析（PD）的ESRD患者的F-水平。在一个饮用水中F-含量为47.4±3.28微摩尔/升（范围44 - 51微摩尔/升）的社区中，招募了17名健康对照者（12名男性，5名女性）和39名接受透析的ESRD患者（17名男性，22名女性）。对照者血清F-平均浓度为1.08±0.350微摩尔/升。对照组男性的F-水平（1.15±0.334，范围0.55 - 1.9微摩尔/升）略高于女性（0.92±0.370，范围0.6 - 1.5微摩尔/升）。对照者中，血清F-平均浓度与年龄和性别无显著相关性，而在接受透析的ESRD患者中观察到这种相关性。接受透析的患者血清F-平均浓度（2.67±1.09，范围0.8 - 5.2微摩尔/升）显著高于正常对照者。按性别分组时，男性血清F-平均浓度（3.05±1.04，范围1.8 - 5.2微摩尔/升）显著高于女性（2.38±1.08，范围0.8 - 5.2微摩尔/升）。按年龄对患者分组时，观察到21 - 70岁年龄组患者的F-浓度（2.86±1.05）显著高于13 - 20岁年龄组患者（1.42±0.531）。因此，F-浓度与年龄和性别相关，男性及20岁以上者浓度更高。尽管F-可通过腹膜有可观的清除率（39% - 90%），但持续非卧床腹膜透析（CAPD）患者的血清F-浓度高于血液透析（HD）患者（3.1±1.97对2.5±1.137微摩尔/升）。在39名接受透析的患者中，39%的患者血清F-浓度高于3.0微摩尔/升，存在肾性骨营养不良风险。
