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吴茱萸碱和吴茱萸次碱对培养的小鼠巨噬细胞一氧化氮产生的抑制作用。

Inhibitory effect of dehydroevodiamine and evodiamine on nitric oxide production in cultured murine macrophages.

作者信息

Chiou W F, Sung Y J, Liao J F, Shum A Y, Chen C F

机构信息

National Research Institute of Chinese Medicine, Shih-Pai, Taipei, Taiwan, Republic of China.

出版信息

J Nat Prod. 1997 Jul;60(7):708-11. doi: 10.1021/np960495z.

DOI:10.1021/np960495z
PMID:9249975
Abstract

Possible antiinflammatory effects of dehydroevodiamine (1) and evodiamine (2) were examined by assessing their effects on NO production in the murine macrophage-like cell line RAW 264.7. The results indicated that both 1 and 2 inhibited the IFN-gamma/LPS-stimulated NO production in a concentration-dependent manner. However, 1 appeared to inhibit NO production by interfering not only with the priming signal initiated by IFN-gamma but also with iNOS protein synthesis, while 2 affected the former only.

摘要

通过评估去氢吴茱萸碱（1）和吴茱萸碱（2）对小鼠巨噬细胞样细胞系RAW 264.7中一氧化氮（NO）生成的影响，研究了它们可能的抗炎作用。结果表明，1和2均以浓度依赖性方式抑制IFN-γ/LPS刺激的NO生成。然而，1似乎不仅通过干扰IFN-γ引发的启动信号，还通过干扰诱导型一氧化氮合酶（iNOS）蛋白合成来抑制NO生成，而2仅影响前者。

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