Cantillo J, Goldberg M E, Larijani G E, Vekeman D
Department of Anesthesiology, Cooper Hospital/University Medical Center, UMDNJ-Robert Wood Johnson Medical School at Camden, New Jersey 08103, USA.
Pharmacotherapy. 1997 Jul-Aug;17(4):779-82.
We compared recovery times in patients with American Society of Anesthesiologists physical status I-III receiving sevoflurane or isoflurane during surgical procedures longer than 1 hour in duration. Of the 50 patients enrolled, 23 received sevoflurane and 27 received isoflurane. Anesthetic gases were discontinued abruptly at the end of the surgical procedure. The following parameters were recorded: time to emergence (opens eyes), time to extubation, response to verbal command (squeezes hand of observer), and orientation (time and place). Exposure times to the agents were similar. The time to emergence was significantly less with sevoflurane than with isoflurane (5.6 vs 11.2 min, respectively). There were no significant differences in time to extubation, response to verbal command, or orientation between the groups. Our data support more rapid emergence with sevoflurane than with isoflurane in surgical procedures longer than 1 hour in duration.
我们比较了美国麻醉医师协会身体状况分级为I - III级、手术时间超过1小时的患者在手术过程中接受七氟醚或异氟醚麻醉后的恢复时间。在纳入的50例患者中，23例接受七氟醚麻醉，27例接受异氟醚麻醉。手术结束时麻醉气体突然停止使用。记录了以下参数：苏醒时间（睁眼）、拔管时间、对言语指令的反应（挤压观察者的手）和定向力（时间和地点）。两种药物的暴露时间相似。七氟醚组的苏醒时间明显短于异氟醚组（分别为5.6分钟和11.2分钟）。两组在拔管时间、对言语指令的反应或定向力方面没有显著差异。我们的数据支持在手术时间超过1小时的手术中，七氟醚比异氟醚能使患者更快苏醒。
