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迟发性小脑共济失调——恶性疟原虫疟疾的一种并发症。

Delayed cerebellar ataxia--a complication of Plasmodium falciparum malaria.

作者信息

Kochar D K, Kumawat B L, Kochar S K, Bajiya H N, Maurya R K

出版信息

J Assoc Physicians India. 1996 Oct;44(10):686-8.

PMID:9251340
Abstract

Cerebellar ataxia is an unusual post malarial complication. We encountered 10 patients of this disease (3 in 1992 and 7 in 1994) during the malaria epidemic period in Bikaner, Rajasthan. All patients were permanent residents to malaria endemic areas. The ataxic symptoms appeared after an afebrile period of 2-7 days. The neurological examination revealed no other abnormality except a cerebellar syndrome interfering with normal gait and speech. Lower limbs were affected more than the upper limbs and the mean delay between onset of fever and onset of cerebellar ataxia was 13 days. Peripheral blood film of all cases showed gametocytes of Plasmodium falciparum and in two cases schizonts of the same. All the patients improved within one month without any residual deficit. Further follow up for next 4 weeks revealed no abnormality.

摘要

小脑性共济失调是一种不常见的疟疾后并发症。在拉贾斯坦邦比卡内尔的疟疾流行期间,我们遇到了10例这种疾病的患者(1992年3例,1994年7例)。所有患者均为疟疾流行地区的常住居民。共济失调症状出现在无热期2至7天后。神经系统检查显示,除了干扰正常步态和言语的小脑综合征外,没有其他异常。下肢比上肢受影响更严重,发热开始至小脑性共济失调开始的平均间隔时间为13天。所有病例的外周血涂片均显示恶性疟原虫配子体,其中2例显示相同的裂殖体。所有患者在1个月内均有改善,无任何残留缺陷。接下来4周的进一步随访未发现异常。

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