Reed R P, Cooke-Yarborough C M, Jaquiery A L, Grimwood K, Kemp A S, Su J C, Forsyth J R
Microbiology Department, Royal Melbourne Hospital, VIC.
Med J Aust. 1997 Jul 21;167(2):82-4. doi: 10.5694/j.1326-5377.1997.tb138785.x.
Granulomatous amoebic encephalitis caused by Balamuthia mandrillaris is rare (63 human) cases reported worldwide) and fatal. We report a case in a five-year-old boy who had previously been well. For 18 months, he had had a slowly progressive, granulomatous mid facial lesion, but despite extensive investigation definitive diagnosis was made only with the acute onset of neurological signs in the last two weeks of life, when a brain biopsy specimen revealed amoebic trophozoites and cysts. Infection with B. mandrillaris should be considered in the differential diagnosis of chronic skin lesions with non-specific granulomatous histopathology and negative microbiological test results.
由曼氏巴贝斯虫引起的肉芽肿性阿米巴脑炎很罕见（全球报告63例人类病例）且具有致命性。我们报告一例5岁男孩的病例，该男孩之前一直健康。18个月来，他面部中部有一个缓慢进展的肉芽肿性病变，但尽管进行了广泛检查，直到生命最后两周出现急性神经症状时才明确诊断，当时脑活检标本显示有阿米巴滋养体和包囊。对于组织病理学为非特异性肉芽肿且微生物检测结果为阴性的慢性皮肤病变，鉴别诊断时应考虑曼氏巴贝斯虫感染。
