Kusumakumari P, Geetha N, Chellam V G, Nair M K
Division of Paediatric Oncology, Regional Cancer Center, Trivandrum, Kerala, India.
Med Pediatr Oncol. 1997 Oct;29(4):303-7. doi: 10.1002/(sici)1096-911x(199710)29:4<303::aid-mpo12>3.0.co;2-b.
Extragonadal germ cell tumors of the head and neck region account for only 5% of all benign and malignant germ cell tumors. Endodermal sinus tumors (EST) of the head and neck region are rare. We report three patients with EST of head and neck region over a period of 10 years; the primary sites of tumor were orbit, maxillofacial region and retroauricular region. Histopathological examination revealed malignant teratoma with predominant endodermal sinus pattern in two, and pure EST in one patient. Serum alpha fetoprotein (AFP) was elevated in all three patients. Two patients had initial surgery but did not receive adjuvant chemotherapy, as the parents refused it. Partial remission was achieved in the other patient who received chemotherapy (cisplatin, bleomycin and vinblastin) and the patient died of infection after four courses of chemotherapy.
头颈部区域的性腺外生殖细胞肿瘤仅占所有良性和恶性生殖细胞肿瘤的5%。头颈部区域的内胚窦瘤（EST）很罕见。我们报告了10年间3例头颈部区域EST患者；肿瘤的原发部位分别为眼眶、颌面区域和耳后区域。组织病理学检查显示，2例为主要呈内胚窦模式的恶性畸胎瘤，1例为单纯EST。所有3例患者血清甲胎蛋白（AFP）均升高。2例患者起初接受了手术，但由于家长拒绝，未接受辅助化疗。另1例接受化疗（顺铂、博来霉素和长春花碱）的患者病情部分缓解，在4个疗程化疗后死于感染。
