Kebudi R, Ayan I, Darendeliler E, Ağaoğlu L, Kinay M, Olgaç V, Bilge N
Department of Pediatric Oncology, University of Istanbul, Turkey.
Med Pediatr Oncol. 1993;21(9):685-9. doi: 10.1002/mpo.2950210915.
Germ cell tumors, in particular teratomas, are some of the most commonly found tumors in childhood. Six percent of all germ cell tumors are located in the head and neck region. Endodermal sinus tumors (yolk sac tumors) of the head and neck, exclusive of the central nervous system, are rare. This study reports a 20-month-old girl with a mass of 5 x 5 cm on the left temporal area and with bone destruction on CT. The histopathological examination of the excised mass revealed an endodermal sinus tumor. The serum AFP and the LDH levels were elevated at diagnosis. The patient was treated by the BEP protocol (bleomycin, etoposide, and cisplatin), six cycles every three weeks. Partial response was attained after the first and complete response after the fourth cycle. The patient, who is being followed up, has been in remission for five months.
生殖细胞肿瘤，尤其是畸胎瘤，是儿童时期最常见的肿瘤类型之一。所有生殖细胞肿瘤中有6%位于头颈部区域。头颈部（不包括中枢神经系统）的内胚窦瘤（卵黄囊瘤）较为罕见。本研究报告了一名20个月大的女童，其左侧颞区有一个5×5厘米的肿块，CT检查显示有骨质破坏。切除肿块的组织病理学检查显示为内胚窦瘤。诊断时血清甲胎蛋白（AFP）和乳酸脱氢酶（LDH）水平升高。患者接受了BEP方案（博来霉素、依托泊苷和顺铂）治疗，每三周进行六个周期。第一个周期后获得部分缓解，第四个周期后获得完全缓解。正在接受随访的患者已缓解五个月。
