向大鼠中央杏仁核注射6-羟基多巴胺损伤可消除血管紧张素对大鼠物体识别的促进作用。

6-OHDA lesions to the central amygdala abolish angiotensins facilitation of object recognition in rats.

Winnicka M M, Braszko J J

Department of Pharmacology, Medical Academy of Białystok, Poland.

Gen Pharmacol. 1997 Aug;29(2):239-43. doi: 10.1016/s0306-3623(96)00401-6.

Abstract

We have previously reported that the dopaminergic projection from A10 ventral tegmental neurons and A9 neurons of substantia nigra to the central amygdala (CA) is, in part, responsible for the facilitatory effect of angiotensin II (AII) and its 3-7 fragment [AII(3-7)] on the retrieval of information in memory that is motivated affectively. 2. In this study, the influence of both angiotensins, given intracerebroventricularly at the dose of 1 nmol each in rats lesioned with 6-OHDA to CA, on recognition memory, was tested. 3. AII and its 3-7 fragment significantly improved object recognition in sham-operated groups of rats. Bilateral 6-OHDA lesions to CA totally abolished the facilitatory effect of both angiotensins on object recognition. As insignificant increase of spontaneous locomotor activity in rats lesioned to CA did not interfere with the cognitive effect of AII and AII(3-7). 4. These results suggest that the dopaminergic projection at the CA takes part in the facilitatory effect of angiotensins on recognition memory.

摘要

我们之前曾报道，从黑质A9神经元和A10腹侧被盖区神经元到中央杏仁核（CA）的多巴胺能投射，部分介导了血管紧张素II（AII）及其3-7片段[AII(3-7)]对情感驱动记忆信息提取的促进作用。2. 在本研究中，对用6-羟基多巴胺（6-OHDA）损毁CA的大鼠，以每侧脑室注射1 nmol的剂量给予两种血管紧张素，测试其对识别记忆的影响。3. AII及其3-7片段显著改善了假手术组大鼠的物体识别能力。双侧CA区6-OHDA损毁完全消除了两种血管紧张素对物体识别的促进作用。由于CA区损毁大鼠的自发运动活动无显著增加，因此不干扰AII和AII(3-7)的认知效应。4. 这些结果表明，CA区的多巴胺能投射参与了血管紧张素对识别记忆的促进作用。