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6-OHDA bilateral lesions to the central amygdala do not affect vasopressin improvement of recall in rats.

作者信息

Winnicka M M

机构信息

Department of Pharmacology, Medical Academy, Białystok, Poland.

出版信息

Acta Neurobiol Exp (Wars). 1996;56(4):943-8. doi: 10.55782/ane-1996-1201.

DOI:10.55782/ane-1996-1201
PMID:9033129
Abstract

The influence of vasopressin (AVP) on recall of information in a passive avoidance situation after bilateral 6-OHDA lesions to the central amygdala was tested. AVP given 15 min before the retention testing at the icv dose of 1 microgram significantly prolonged avoidance latencies both in lesioned and in sham-operated rats in comparison with the respective icv saline injected animals. Insignificant increase of spontaneous locomotor activity in rats lesioned to the central amygdala was unlikely to interfere with the cognitive effect of AVP. These results suggest that dopaminergic projection to the central amygdala is not responsible for the facilitatory effect of AVP on retrieval process in a passive avoidance situation.

摘要

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