Winnicka M M, Braszko J J, Wiśniewski K
Department of Pharmacology, Medical Academy of Białystok, Poland.
Pharmacol Res. 1997 Nov;36(5):387-94. doi: 10.1006/phrs.1997.0257.
We have previously reported that the dopaminergic projection from A10 ventral tegmental neurons to the central amygdala is, in part, responsible for the facilitatory effect of angiotensin II (AII) and its 3-7 fragment [AII(3-7)] on the retrieval of information in memory motivated affectively and also on recognition memory. In this study, the influence of both angiotensins, given intracerebroventricularly at the dose of 1 nmol each, in rats lesioned with 6-OHDA to the nucleus accumbens septi (NAS) and to the nucleus septi lateralis (NSL) on recognition memory was evaluated. AII and its 3-7 fragment significantly improved object recognition in sham-operated to NAS and to NSL groups of rats. Bilateral 6-OHDA lesions to NAS totally abolished and to NSL significantly attenuated the facilitatory effect of both angiotensins on object recognition. These results suggest that the dopaminergic projection arriving to the septal structures. NAS and NSL takes part in the facilitatory effect of angiotensins on recognition memory.
我们之前曾报道，从A10腹侧被盖区神经元到中央杏仁核的多巴胺能投射，部分上介导了血管紧张素II（AII）及其3-7片段[AII(3-7)]对情感驱动记忆中信息提取以及识别记忆的促进作用。在本研究中，我们评估了分别以1 nmol的剂量脑室内注射这两种血管紧张素，对6-羟基多巴胺（6-OHDA）损毁伏隔核（NAS）和外侧隔核（NSL）的大鼠识别记忆的影响。AII及其3-7片段显著改善了假手术组到NAS组和NSL组大鼠的物体识别能力。双侧6-OHDA损毁NAS完全消除了，而损毁NSL则显著减弱了这两种血管紧张素对物体识别的促进作用。这些结果表明，到达隔区结构NAS和NSL的多巴胺能投射参与了血管紧张素对识别记忆的促进作用。
